Model‐Based Analysis of Unbound Lopinavir Pharmacokinetics in HIV‐Infected Pregnant Women Supports Standard Dosing in the Third Trimester

Physiological changes during pregnancy can affect drug pharmacokinetics. Here we present a population pharmacokinetic model to describe the longitudinal change of unbound lopinavir/ritonavir (LPV/RTV) PK parameters with gestational age, and to predict unbound LPV concentrations under different dosin...

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Detalles Bibliográficos
Autores principales: Chen, J, Malone, S, Prince, HMA, Patterson, KB, Dumond, JB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807435/
https://www.ncbi.nlm.nih.gov/pubmed/27069778
http://dx.doi.org/10.1002/psp4.12065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807435/
https://www.ncbi.nlm.nih.gov/pubmed/27069778
http://dx.doi.org/10.1002/psp4.12065

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