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Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style

Saccadic suppression—the reduction of visual sensitivity during rapid eye movements—has previously been proposed to reflect a specific suppression of the magnocellular visual system, with the initial neural site of that suppression at or prior to afferent visual information reaching striate cortex....

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Autores principales: Crewther, David P., Crewther, Daniel, Bevan, Stephanie, Goodale, Melvyn A., Crewther, Sheila G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807440/
https://www.ncbi.nlm.nih.gov/pubmed/27019719
http://dx.doi.org/10.1098/rsos.150226
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author Crewther, David P.
Crewther, Daniel
Bevan, Stephanie
Goodale, Melvyn A.
Crewther, Sheila G.
author_facet Crewther, David P.
Crewther, Daniel
Bevan, Stephanie
Goodale, Melvyn A.
Crewther, Sheila G.
author_sort Crewther, David P.
collection PubMed
description Saccadic suppression—the reduction of visual sensitivity during rapid eye movements—has previously been proposed to reflect a specific suppression of the magnocellular visual system, with the initial neural site of that suppression at or prior to afferent visual information reaching striate cortex. Dysfunction in the magnocellular visual pathway has also been associated with perceptual and physiological anomalies in individuals with autism spectrum disorder or high autistic tendency, leading us to question whether saccadic suppression is altered in the broader autism phenotype. Here we show that individuals with high autistic tendency show greater saccadic suppression of low versus high spatial frequency gratings while those with low autistic tendency do not. In addition, those with high but not low autism spectrum quotient (AQ) demonstrated pre-cortical (35–45 ms) evoked potential differences (saccade versus fixation) to a large, low contrast, pseudo-randomly flashing bar. Both AQ groups showed similar differential visual evoked potential effects in later epochs (80–160 ms) at high contrast. Thus, the magnocellular theory of saccadic suppression appears untenable as a general description for the typically developing population. Our results also suggest that the bias towards local perceptual style reported in autism may be due to selective suppression of low spatial frequency information accompanying every saccadic eye movement.
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spelling pubmed-48074402016-03-25 Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style Crewther, David P. Crewther, Daniel Bevan, Stephanie Goodale, Melvyn A. Crewther, Sheila G. R Soc Open Sci Psychology and Cognitive Neuroscience Saccadic suppression—the reduction of visual sensitivity during rapid eye movements—has previously been proposed to reflect a specific suppression of the magnocellular visual system, with the initial neural site of that suppression at or prior to afferent visual information reaching striate cortex. Dysfunction in the magnocellular visual pathway has also been associated with perceptual and physiological anomalies in individuals with autism spectrum disorder or high autistic tendency, leading us to question whether saccadic suppression is altered in the broader autism phenotype. Here we show that individuals with high autistic tendency show greater saccadic suppression of low versus high spatial frequency gratings while those with low autistic tendency do not. In addition, those with high but not low autism spectrum quotient (AQ) demonstrated pre-cortical (35–45 ms) evoked potential differences (saccade versus fixation) to a large, low contrast, pseudo-randomly flashing bar. Both AQ groups showed similar differential visual evoked potential effects in later epochs (80–160 ms) at high contrast. Thus, the magnocellular theory of saccadic suppression appears untenable as a general description for the typically developing population. Our results also suggest that the bias towards local perceptual style reported in autism may be due to selective suppression of low spatial frequency information accompanying every saccadic eye movement. The Royal Society Publishing 2015-12-16 /pmc/articles/PMC4807440/ /pubmed/27019719 http://dx.doi.org/10.1098/rsos.150226 Text en http://creativecommons.org/licenses/by/4.0/ © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Psychology and Cognitive Neuroscience
Crewther, David P.
Crewther, Daniel
Bevan, Stephanie
Goodale, Melvyn A.
Crewther, Sheila G.
Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style
title Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style
title_full Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style
title_fullStr Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style
title_full_unstemmed Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style
title_short Greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style
title_sort greater magnocellular saccadic suppression in high versus low autistic tendency suggests a causal path to local perceptual style
topic Psychology and Cognitive Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807440/
https://www.ncbi.nlm.nih.gov/pubmed/27019719
http://dx.doi.org/10.1098/rsos.150226
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