Combined Analysis of Phase I and Phase II Data to Enhance the Power of Pharmacogenetic Tests

We show through a simulation study how the joint analysis of data from phase I and phase II studies enhances the power of pharmacogenetic tests in pharmacokinetic (PK) studies. PK profiles were simulated under different designs along with 176 genetic markers. The null scenarios assumed no genetic ef...

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Detalles Bibliográficos
Autores principales: Tessier, A, Bertrand, J, Chenel, M, Comets, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807465/
https://www.ncbi.nlm.nih.gov/pubmed/27069775
http://dx.doi.org/10.1002/psp4.12054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807465/
https://www.ncbi.nlm.nih.gov/pubmed/27069775
http://dx.doi.org/10.1002/psp4.12054

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