A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling

Evidence is accumulating for the role of cancer stem cells (CSCs) in mediating chemoresistance in patients with metastatic colorectal cancer (mCRC). A disintegrin and metalloproteinase domain 17 (ADAM17; also known as tumor necrosis factor-α-converting enzyme [TACE]) was shown to be overexpressed an...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Ye, Xiangcang, Bhattacharya, Rajat, Boulbes, Delphine R., Fan, Fan, Xia, Ling, Ellis, Lee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AlphaMed Press 2016
Materias:
Cancer Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807666/
https://www.ncbi.nlm.nih.gov/pubmed/26744411
http://dx.doi.org/10.5966/sctm.2015-0168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807666/
https://www.ncbi.nlm.nih.gov/pubmed/26744411
http://dx.doi.org/10.5966/sctm.2015-0168

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