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RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

AGEs accumulation in the skin affects extracellular matrix (ECM) turnover and triggers diabetes associated skin conditions and accelerated skin aging. The receptor of AGEs (RAGE) has an essential contribution to cellular dysfunction driven by chronic inflammatory responses while TGF-β1 is critical i...

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Detalles Bibliográficos
Autores principales:	Serban, Andreea Iren, Stanca, Loredana, Geicu, Ovidiu Ionut, Munteanu, Maria Cristina, Dinischiotu, Anca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807770/ https://www.ncbi.nlm.nih.gov/pubmed/27015414 http://dx.doi.org/10.1371/journal.pone.0152376

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