Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons

Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear. Here, using the C. elegans PLM neurons as a...

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Detalles Bibliográficos
Autores principales: Meng, Lingfeng, Chen, Chia-hui, Yan, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807823/
https://www.ncbi.nlm.nih.gov/pubmed/27015090
http://dx.doi.org/10.1371/journal.pgen.1005948
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author Meng, Lingfeng
Chen, Chia-hui
Yan, Dong
author_facet Meng, Lingfeng
Chen, Chia-hui
Yan, Dong
author_sort Meng, Lingfeng
collection PubMed
description Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics, and loss-of-function in the UNC-44/UNC-33/VAB-8 pathway suppresses the turnover of gap junction channels. Therefore, we first show a signal pathway including ankyrin, CRMP, and kinesin in regulating gap junctions.
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spelling pubmed-48078232016-04-05 Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons Meng, Lingfeng Chen, Chia-hui Yan, Dong PLoS Genet Research Article Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics, and loss-of-function in the UNC-44/UNC-33/VAB-8 pathway suppresses the turnover of gap junction channels. Therefore, we first show a signal pathway including ankyrin, CRMP, and kinesin in regulating gap junctions. Public Library of Science 2016-03-25 /pmc/articles/PMC4807823/ /pubmed/27015090 http://dx.doi.org/10.1371/journal.pgen.1005948 Text en © 2016 Meng et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Meng, Lingfeng
Chen, Chia-hui
Yan, Dong
Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons
title Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons
title_full Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons
title_fullStr Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons
title_full_unstemmed Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons
title_short Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons
title_sort regulation of gap junction dynamics by unc-44/ankyrin and unc-33/crmp through vab-8 in c. elegans neurons
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807823/
https://www.ncbi.nlm.nih.gov/pubmed/27015090
http://dx.doi.org/10.1371/journal.pgen.1005948
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