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The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila

The insulin/IGF-1 signaling pathway mediates various physiological processes associated with human health. Components of this pathway are highly conserved throughout eukaryotic evolution. In Drosophila, the PTEN ortholog and its mammalian counterpart downregulate insulin/IGF signaling by antagonizin...

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Detalles Bibliográficos
Autores principales:	Chang, Ying-Ju, Zhou, Lily, Binari, Richard, Manoukian, Armen, Mak, Tak, McNeill, Helen, Stambolic, Vuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807833/ https://www.ncbi.nlm.nih.gov/pubmed/27015411 http://dx.doi.org/10.1371/journal.pone.0152259

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