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Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review
Lipid-rich carcinoma (LRC) of the breast is a rare breast cancer variant that accounts for <1% of all breast malignancies. It has been reported that LRCs are negative for estrogen receptor. Here, we report a case of LRC of the breast that was strongly positive for estrogen receptor and treated wi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807953/ https://www.ncbi.nlm.nih.gov/pubmed/27051299 http://dx.doi.org/10.2147/OTT.S88726 |
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author | Oba, Takaaki Ono, Mayu Iesato, Asumi Hanamura, Toru Watanabe, Takayuki Ito, Tokiko Kanai, Toshiharu Maeno, Kazuma Ito, Ken-ichi Tateishi, Ayako Yoshizawa, Akihiko Takayama, Fumiyoshi |
author_facet | Oba, Takaaki Ono, Mayu Iesato, Asumi Hanamura, Toru Watanabe, Takayuki Ito, Tokiko Kanai, Toshiharu Maeno, Kazuma Ito, Ken-ichi Tateishi, Ayako Yoshizawa, Akihiko Takayama, Fumiyoshi |
author_sort | Oba, Takaaki |
collection | PubMed |
description | Lipid-rich carcinoma (LRC) of the breast is a rare breast cancer variant that accounts for <1% of all breast malignancies. It has been reported that LRCs are negative for estrogen receptor. Here, we report a case of LRC of the breast that was strongly positive for estrogen receptor and treated with endocrine adjuvant therapy. A 52-year-old postmenopausal female noticed a lump in her right breast by self-examination and presented to our hospital. Physical examination revealed an elastic 30 mm ×20 mm hard mass in the upper medial part of her right breast. The findings obtained using ultrasonography, mammography, and contrast-enhanced magnetic resonance imaging suggested breast cancer. Core needle biopsy resulted in the diagnosis of invasive carcinoma. The patient underwent mastectomy and sentinel lymph node biopsy. Histopathologically, the tumor cells were abundant in foamy cytoplasm. Because the presence of marked cytoplasmic lipid droplets was confirmed by Sudan IV staining and electron microscopic examination of the tumor and the lipid droplets were negative for periodic acid–Schiff staining, the tumor was diagnosed as an LRC. Immunohistochemically, estrogen and progesterone receptors of the tumor were strongly positive, human epidermal growth factor receptor type 2 was negative, and the ratio of Ki-67-positive cells was ~30%. After surgery, the patient underwent combination chemotherapy with anthracycline, cyclophosphamide, and 5-fluorouracil, followed by docetaxel. Thereafter, the pateint was treated with letrozole and has remained well for 24 months with no signs of recurrence. |
format | Online Article Text |
id | pubmed-4807953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48079532016-04-05 Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review Oba, Takaaki Ono, Mayu Iesato, Asumi Hanamura, Toru Watanabe, Takayuki Ito, Tokiko Kanai, Toshiharu Maeno, Kazuma Ito, Ken-ichi Tateishi, Ayako Yoshizawa, Akihiko Takayama, Fumiyoshi Onco Targets Ther Case Report Lipid-rich carcinoma (LRC) of the breast is a rare breast cancer variant that accounts for <1% of all breast malignancies. It has been reported that LRCs are negative for estrogen receptor. Here, we report a case of LRC of the breast that was strongly positive for estrogen receptor and treated with endocrine adjuvant therapy. A 52-year-old postmenopausal female noticed a lump in her right breast by self-examination and presented to our hospital. Physical examination revealed an elastic 30 mm ×20 mm hard mass in the upper medial part of her right breast. The findings obtained using ultrasonography, mammography, and contrast-enhanced magnetic resonance imaging suggested breast cancer. Core needle biopsy resulted in the diagnosis of invasive carcinoma. The patient underwent mastectomy and sentinel lymph node biopsy. Histopathologically, the tumor cells were abundant in foamy cytoplasm. Because the presence of marked cytoplasmic lipid droplets was confirmed by Sudan IV staining and electron microscopic examination of the tumor and the lipid droplets were negative for periodic acid–Schiff staining, the tumor was diagnosed as an LRC. Immunohistochemically, estrogen and progesterone receptors of the tumor were strongly positive, human epidermal growth factor receptor type 2 was negative, and the ratio of Ki-67-positive cells was ~30%. After surgery, the patient underwent combination chemotherapy with anthracycline, cyclophosphamide, and 5-fluorouracil, followed by docetaxel. Thereafter, the pateint was treated with letrozole and has remained well for 24 months with no signs of recurrence. Dove Medical Press 2016-03-18 /pmc/articles/PMC4807953/ /pubmed/27051299 http://dx.doi.org/10.2147/OTT.S88726 Text en © 2016 Oba et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Oba, Takaaki Ono, Mayu Iesato, Asumi Hanamura, Toru Watanabe, Takayuki Ito, Tokiko Kanai, Toshiharu Maeno, Kazuma Ito, Ken-ichi Tateishi, Ayako Yoshizawa, Akihiko Takayama, Fumiyoshi Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review |
title | Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review |
title_full | Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review |
title_fullStr | Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review |
title_full_unstemmed | Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review |
title_short | Lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review |
title_sort | lipid-rich carcinoma of the breast that is strongly positive for estrogen receptor: a case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807953/ https://www.ncbi.nlm.nih.gov/pubmed/27051299 http://dx.doi.org/10.2147/OTT.S88726 |
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