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The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis

Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4(+) T cells. However, the role of TRPV1 in CD4(+) T cell in allergic rhiniti...

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Autores principales: Samivel, Ramachandran, Kim, Dae Woo, Son, Hye Ran, Rhee, Yun-Hee, Kim, Eun Hee, Kim, Ji Hye, Bae, Jun-Sang, Chung, Young-Jun, Chung, Phil-Sang, Raz, Eyal, Mo, Ji-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807989/
https://www.ncbi.nlm.nih.gov/pubmed/26700618
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author Samivel, Ramachandran
Kim, Dae Woo
Son, Hye Ran
Rhee, Yun-Hee
Kim, Eun Hee
Kim, Ji Hye
Bae, Jun-Sang
Chung, Young-Jun
Chung, Phil-Sang
Raz, Eyal
Mo, Ji-Hun
author_facet Samivel, Ramachandran
Kim, Dae Woo
Son, Hye Ran
Rhee, Yun-Hee
Kim, Eun Hee
Kim, Ji Hye
Bae, Jun-Sang
Chung, Young-Jun
Chung, Phil-Sang
Raz, Eyal
Mo, Ji-Hun
author_sort Samivel, Ramachandran
collection PubMed
description Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4(+) T cells. However, the role of TRPV1 in CD4(+) T cell in allergic rhinitis remains poorly understood. In this study, TRPV1 expression was localized in CD4(+) T cells. Both knockout and chemical inhibition of TRPV1 suppressed Th2/Th17 cytokine production in CD4 T cells and Jurkat T cells, respectively, and can suppress T cell receptor signaling pathways including NF-κB, MAP kinase, and NFAT. In TRPV1 knockout allergic rhinitis (AR) mice, eosinophil infiltration, Th2/Th17 cytokines in the nasal mucosa, and total and ova-specific IgE levels in serum decreased, compared with wild-type AR mice. The TRPV1 antagonists, BCTC or theobromine, showed similar inhibitory immunologic effects on AR mice models. In addition, the number of TRPV1(+)/CD4(+) inflammatory cells increased in the nasal mucosa of patients with AR, compared with that of control subjects. Thus, TRPV1 activation on CD4(+) T cells is involved in T cell receptor signaling, and it could be a novel therapeutic target in AR.
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spelling pubmed-48079892016-04-19 The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis Samivel, Ramachandran Kim, Dae Woo Son, Hye Ran Rhee, Yun-Hee Kim, Eun Hee Kim, Ji Hye Bae, Jun-Sang Chung, Young-Jun Chung, Phil-Sang Raz, Eyal Mo, Ji-Hun Oncotarget Research Paper: Immunology Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful stimuli, was reported to regulate the signaling and activation of CD4(+) T cells. However, the role of TRPV1 in CD4(+) T cell in allergic rhinitis remains poorly understood. In this study, TRPV1 expression was localized in CD4(+) T cells. Both knockout and chemical inhibition of TRPV1 suppressed Th2/Th17 cytokine production in CD4 T cells and Jurkat T cells, respectively, and can suppress T cell receptor signaling pathways including NF-κB, MAP kinase, and NFAT. In TRPV1 knockout allergic rhinitis (AR) mice, eosinophil infiltration, Th2/Th17 cytokines in the nasal mucosa, and total and ova-specific IgE levels in serum decreased, compared with wild-type AR mice. The TRPV1 antagonists, BCTC or theobromine, showed similar inhibitory immunologic effects on AR mice models. In addition, the number of TRPV1(+)/CD4(+) inflammatory cells increased in the nasal mucosa of patients with AR, compared with that of control subjects. Thus, TRPV1 activation on CD4(+) T cells is involved in T cell receptor signaling, and it could be a novel therapeutic target in AR. Impact Journals LLC 2015-12-18 /pmc/articles/PMC4807989/ /pubmed/26700618 Text en Copyright: © 2016 Samivel et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Immunology
Samivel, Ramachandran
Kim, Dae Woo
Son, Hye Ran
Rhee, Yun-Hee
Kim, Eun Hee
Kim, Ji Hye
Bae, Jun-Sang
Chung, Young-Jun
Chung, Phil-Sang
Raz, Eyal
Mo, Ji-Hun
The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis
title The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis
title_full The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis
title_fullStr The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis
title_full_unstemmed The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis
title_short The role of TRPV1 in the CD4(+) T cell-mediated inflammatory response of allergic rhinitis
title_sort role of trpv1 in the cd4(+) t cell-mediated inflammatory response of allergic rhinitis
topic Research Paper: Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807989/
https://www.ncbi.nlm.nih.gov/pubmed/26700618
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