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Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer
N-myc downstream-regulated gene 2 (NDRG2) is a tumor suppressor and cell stress-related gene. NDRG2 is associated with tumor incidence, progression, and metastasis. NDRG2 regulates tumor-associated genes and is regulated by multiple conditions, treatments, and protein/RNA entities, including hyperth...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807993/ https://www.ncbi.nlm.nih.gov/pubmed/26506239 |
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author | Hu, Wei Fan, Chongxi Jiang, Peng Ma, Zhiqiang Yan, Xiaolong Di, Shouyin Jiang, Shuai Li, Tian Cheng, Yedong Yang, Yang |
author_facet | Hu, Wei Fan, Chongxi Jiang, Peng Ma, Zhiqiang Yan, Xiaolong Di, Shouyin Jiang, Shuai Li, Tian Cheng, Yedong Yang, Yang |
author_sort | Hu, Wei |
collection | PubMed |
description | N-myc downstream-regulated gene 2 (NDRG2) is a tumor suppressor and cell stress-related gene. NDRG2 is associated with tumor incidence, progression, and metastasis. NDRG2 regulates tumor-associated genes and is regulated by multiple conditions, treatments, and protein/RNA entities, including hyperthermia, trichostatin A and 5-aza-2′-deoxycytidine, which are promising potential cancer therapeutics. In this review, we discuss the expression as well as the clinical and pathological significance of NDRG2 in cancer. The pathological processes and molecular pathways regulated by NDRG2 are also summarized. Moreover, mechanisms for increasing NDRG2 expression in tumors and the potential directions of future NDRG2 research are discussed. The information reviewed here should assist in experimental design and increase the potential of NDRG2 as a therapeutic target for cancer. |
format | Online Article Text |
id | pubmed-4807993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-48079932016-04-19 Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer Hu, Wei Fan, Chongxi Jiang, Peng Ma, Zhiqiang Yan, Xiaolong Di, Shouyin Jiang, Shuai Li, Tian Cheng, Yedong Yang, Yang Oncotarget Review N-myc downstream-regulated gene 2 (NDRG2) is a tumor suppressor and cell stress-related gene. NDRG2 is associated with tumor incidence, progression, and metastasis. NDRG2 regulates tumor-associated genes and is regulated by multiple conditions, treatments, and protein/RNA entities, including hyperthermia, trichostatin A and 5-aza-2′-deoxycytidine, which are promising potential cancer therapeutics. In this review, we discuss the expression as well as the clinical and pathological significance of NDRG2 in cancer. The pathological processes and molecular pathways regulated by NDRG2 are also summarized. Moreover, mechanisms for increasing NDRG2 expression in tumors and the potential directions of future NDRG2 research are discussed. The information reviewed here should assist in experimental design and increase the potential of NDRG2 as a therapeutic target for cancer. Impact Journals LLC 2015-10-25 /pmc/articles/PMC4807993/ /pubmed/26506239 Text en Copyright: © 2016 Hu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Hu, Wei Fan, Chongxi Jiang, Peng Ma, Zhiqiang Yan, Xiaolong Di, Shouyin Jiang, Shuai Li, Tian Cheng, Yedong Yang, Yang Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer |
title | Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer |
title_full | Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer |
title_fullStr | Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer |
title_full_unstemmed | Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer |
title_short | Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer |
title_sort | emerging role of n-myc downstream-regulated gene 2 (ndrg2) in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807993/ https://www.ncbi.nlm.nih.gov/pubmed/26506239 |
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