Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state

The ATPase Inhibitory Factor 1 (IF1) is an inhibitor of the mitochondrial H(+)-ATP synthase that regulates the activity of both oxidative phosphorylation (OXPHOS) and cell death. Here, we have developed transgenic Tet-On and Tet-Off mice that express a mutant active form of hIF1 in the hepatocytes t...

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Detalles Bibliográficos
Autores principales: Santacatterina, Fulvio, Sánchez-Cenizo, Laura, Formentini, Laura, Mobasher, Maysa A., Casas, Estela, Rueda, Carlos B., Martínez-Reyes, Inmaculada, de Arenas, Cristina Núñez, García-Bermúdez, Javier, Zapata, Juan M., Sánchez-Aragó, María, Satrústegui, Jorgina, Valverde, Ángela M., Cuezva, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808013/
https://www.ncbi.nlm.nih.gov/pubmed/26595676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808013/
https://www.ncbi.nlm.nih.gov/pubmed/26595676

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