Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations

Improved therapies are greatly needed for non-small cell lung cancer (NSCLC) that does not harbor targetable kinase mutations or translocations. We previously demonstrated that NSCLC cells that harbor kinase-inactivating BRAF mutations ((KI)BRAF) undergo senescence when treated with the multitargete...

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Detalles Bibliográficos
Autores principales: Peng, Shaohua, Sen, Banibrata, Mazumdar, Tuhina, Byers, Lauren A., Diao, Lixia, Wang, Jing, Tong, Pan, Giri, Uma, Heymach, John V., Kadara, Humam N., Johnson, Faye M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808018/
https://www.ncbi.nlm.nih.gov/pubmed/26623721

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