The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells

BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and is up-regulated in biliary tract cancer (BTC), contributing to aggressive clinical features. In this study we investigated the cytotoxic effects of PTC-209, a recently developed inhibitor of BMI1, in BTC cells. PTC-209 reduced...

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Detalles Bibliográficos
Autores principales: Mayr, Christian, Wagner, Andrej, Loeffelberger, Magdalena, Bruckner, Daniela, Jakab, Martin, Berr, Frieder, Di Fazio, Pietro, Ocker, Matthias, Neureiter, Daniel, Pichler, Martin, Kiesslich, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808030/
https://www.ncbi.nlm.nih.gov/pubmed/26623561

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