Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition

Several lines of evidence indicate that whole-genome duplication resulting in tetraploidy facilitates carcinogenesis by providing an intermediate and metastable state more prone to generate oncogenic aneuploidy. Here, we report a novel strategy to preferentially kill tetraploid cells based on the ab...

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Detalles Bibliográficos
Autores principales: Jemaà, Mohamed, Manic, Gwenola, Lledo, Gwendaline, Lissa, Delphine, Reynes, Christelle, Morin, Nathalie, Chibon, Frédéric, Sistigu, Antonella, Castedo, Maria, Vitale, Ilio, Kroemer, Guido, Abrieu, Ariane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808040/
https://www.ncbi.nlm.nih.gov/pubmed/26637805

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