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The HMG-CoA reductase inhibitor, simvastatin, exhibits anti-metastatic and anti-tumorigenic effects in ovarian cancer

Ovarian cancer is the 5th leading cause of cancer death among women in the United States. The mevalonate pathway is thought to be a potential oncogenic pathway in the pathogenesis of ovarian cancer. Simvastatin, a 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) inhibitor, is a widely used drug for...

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Detalles Bibliográficos
Autores principales:	Stine, Jessica E., Guo, Hui, Sheng, Xiugui, Han, Xiaoyun, Schointuch, Monica N., Gilliam, Timothy P., Gehrig, Paola A., Zhou, Chunxiao, Bae-Jump, Victoria L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808044/ https://www.ncbi.nlm.nih.gov/pubmed/26503475

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