Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer

Purpose: Non-small-cell lung cancers harboring EML4-ALK rearrangements are sensitive to crizotinib. However, despite initial response, most patients will eventually relapse, and monitoring EML4-ALK rearrangements over the course of treatment may help identify these patients. However, challenges asso...

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Detalles Bibliográficos
Autores principales: Nilsson, R. Jonas A., Karachaliou, Niki, Berenguer, Jordi, Gimenez-Capitan, Ana, Schellen, Pepijn, Teixido, Cristina, Tannous, Jihane, Kuiper, Justine L., Drees, Esther, Grabowska, Magda, van Keulen, Marte, Heideman, Danielle A.M., Thunnissen, Erik, Dingemans, Anne-Marie C., Viteri, Santiago, Tannous, Bakhos A., Drozdowskyj, Ana, Rosell, Rafael, Smit, Egbert F., Wurdinger, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Clinical Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808052/
https://www.ncbi.nlm.nih.gov/pubmed/26544515

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