Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the select...

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Detalles Bibliográficos
Autores principales: Bottery, Michael J., Wood, A. Jamie, Brockhurst, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808222/
https://www.ncbi.nlm.nih.gov/pubmed/26787694
http://dx.doi.org/10.1128/AAC.02441-15
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author Bottery, Michael J.
Wood, A. Jamie
Brockhurst, Michael A.
author_facet Bottery, Michael J.
Wood, A. Jamie
Brockhurst, Michael A.
author_sort Bottery, Michael J.
collection PubMed
description Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.
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spelling pubmed-48082222016-04-04 Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance Bottery, Michael J. Wood, A. Jamie Brockhurst, Michael A. Antimicrob Agents Chemother Susceptibility Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain. American Society for Microbiology 2016-03-25 /pmc/articles/PMC4808222/ /pubmed/26787694 http://dx.doi.org/10.1128/AAC.02441-15 Text en Copyright © 2016 Bottery et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Susceptibility
Bottery, Michael J.
Wood, A. Jamie
Brockhurst, Michael A.
Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
title Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
title_full Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
title_fullStr Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
title_full_unstemmed Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
title_short Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance
title_sort selective conditions for a multidrug resistance plasmid depend on the sociality of antibiotic resistance
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808222/
https://www.ncbi.nlm.nih.gov/pubmed/26787694
http://dx.doi.org/10.1128/AAC.02441-15
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