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Hepatitis E virus as an emerging zoonotic pathogen
Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HE...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Veterinary Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808633/ https://www.ncbi.nlm.nih.gov/pubmed/27051334 http://dx.doi.org/10.4142/jvs.2016.17.1.1 |
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author | Park, Woo-Jung Park, Byung-Joo Ahn, Hee-Seop Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Yoo, Han-Sang Choi, In-Soo |
author_facet | Park, Woo-Jung Park, Byung-Joo Ahn, Hee-Seop Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Yoo, Han-Sang Choi, In-Soo |
author_sort | Park, Woo-Jung |
collection | PubMed |
description | Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HEV), has been isolated from several animal species, including pigs. HEV genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. Seroprevalence studies in animals and humans indirectly suggest that HEV infections occur worldwide. The virus is primarily transmitted to humans via undercooked animal meats in developed countries. Moreover, transfusion- and transplantation-mediated HEV infections have recently been reported. This review summarizes the general characteristics of hepatitis E, HEV infection status in animals and humans, the zoonotic transmission modes of HEV, and HEV vaccine development status. |
format | Online Article Text |
id | pubmed-4808633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48086332016-04-05 Hepatitis E virus as an emerging zoonotic pathogen Park, Woo-Jung Park, Byung-Joo Ahn, Hee-Seop Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Yoo, Han-Sang Choi, In-Soo J Vet Sci Review Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HEV), has been isolated from several animal species, including pigs. HEV genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. Seroprevalence studies in animals and humans indirectly suggest that HEV infections occur worldwide. The virus is primarily transmitted to humans via undercooked animal meats in developed countries. Moreover, transfusion- and transplantation-mediated HEV infections have recently been reported. This review summarizes the general characteristics of hepatitis E, HEV infection status in animals and humans, the zoonotic transmission modes of HEV, and HEV vaccine development status. The Korean Society of Veterinary Science 2016-03 2016-03-22 /pmc/articles/PMC4808633/ /pubmed/27051334 http://dx.doi.org/10.4142/jvs.2016.17.1.1 Text en © 2016 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Park, Woo-Jung Park, Byung-Joo Ahn, Hee-Seop Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Yoo, Han-Sang Choi, In-Soo Hepatitis E virus as an emerging zoonotic pathogen |
title | Hepatitis E virus as an emerging zoonotic pathogen |
title_full | Hepatitis E virus as an emerging zoonotic pathogen |
title_fullStr | Hepatitis E virus as an emerging zoonotic pathogen |
title_full_unstemmed | Hepatitis E virus as an emerging zoonotic pathogen |
title_short | Hepatitis E virus as an emerging zoonotic pathogen |
title_sort | hepatitis e virus as an emerging zoonotic pathogen |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808633/ https://www.ncbi.nlm.nih.gov/pubmed/27051334 http://dx.doi.org/10.4142/jvs.2016.17.1.1 |
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