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Hepatitis E virus as an emerging zoonotic pathogen

Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HE...

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Autores principales: Park, Woo-Jung, Park, Byung-Joo, Ahn, Hee-Seop, Lee, Joong-Bok, Park, Seung-Yong, Song, Chang-Seon, Lee, Sang-Won, Yoo, Han-Sang, Choi, In-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808633/
https://www.ncbi.nlm.nih.gov/pubmed/27051334
http://dx.doi.org/10.4142/jvs.2016.17.1.1
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author Park, Woo-Jung
Park, Byung-Joo
Ahn, Hee-Seop
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Yoo, Han-Sang
Choi, In-Soo
author_facet Park, Woo-Jung
Park, Byung-Joo
Ahn, Hee-Seop
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Yoo, Han-Sang
Choi, In-Soo
author_sort Park, Woo-Jung
collection PubMed
description Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HEV), has been isolated from several animal species, including pigs. HEV genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. Seroprevalence studies in animals and humans indirectly suggest that HEV infections occur worldwide. The virus is primarily transmitted to humans via undercooked animal meats in developed countries. Moreover, transfusion- and transplantation-mediated HEV infections have recently been reported. This review summarizes the general characteristics of hepatitis E, HEV infection status in animals and humans, the zoonotic transmission modes of HEV, and HEV vaccine development status.
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spelling pubmed-48086332016-04-05 Hepatitis E virus as an emerging zoonotic pathogen Park, Woo-Jung Park, Byung-Joo Ahn, Hee-Seop Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Yoo, Han-Sang Choi, In-Soo J Vet Sci Review Hepatitis E outbreaks are a serious public health concern in developing countries. The disease causes acute infections, primarily in young adults. The mortality rate is approximately 2%; however, it can exceed 20% in pregnant women in some regions in India. The causative agent, hepatitis E virus (HEV), has been isolated from several animal species, including pigs. HEV genotypes 3 and 4 have been isolated from both humans and animals, and are recognized as zoonotic pathogens. Seroprevalence studies in animals and humans indirectly suggest that HEV infections occur worldwide. The virus is primarily transmitted to humans via undercooked animal meats in developed countries. Moreover, transfusion- and transplantation-mediated HEV infections have recently been reported. This review summarizes the general characteristics of hepatitis E, HEV infection status in animals and humans, the zoonotic transmission modes of HEV, and HEV vaccine development status. The Korean Society of Veterinary Science 2016-03 2016-03-22 /pmc/articles/PMC4808633/ /pubmed/27051334 http://dx.doi.org/10.4142/jvs.2016.17.1.1 Text en © 2016 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Park, Woo-Jung
Park, Byung-Joo
Ahn, Hee-Seop
Lee, Joong-Bok
Park, Seung-Yong
Song, Chang-Seon
Lee, Sang-Won
Yoo, Han-Sang
Choi, In-Soo
Hepatitis E virus as an emerging zoonotic pathogen
title Hepatitis E virus as an emerging zoonotic pathogen
title_full Hepatitis E virus as an emerging zoonotic pathogen
title_fullStr Hepatitis E virus as an emerging zoonotic pathogen
title_full_unstemmed Hepatitis E virus as an emerging zoonotic pathogen
title_short Hepatitis E virus as an emerging zoonotic pathogen
title_sort hepatitis e virus as an emerging zoonotic pathogen
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808633/
https://www.ncbi.nlm.nih.gov/pubmed/27051334
http://dx.doi.org/10.4142/jvs.2016.17.1.1
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