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Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs
To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was als...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Veterinary Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808635/ https://www.ncbi.nlm.nih.gov/pubmed/27051347 http://dx.doi.org/10.4142/jvs.2016.17.1.111 |
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author | Ponchon, Tamara Lopez Merlo, Mariana Faya, Marcela Priotto, Marcelo Barbeito, Claudio Gobello, Cristina |
author_facet | Ponchon, Tamara Lopez Merlo, Mariana Faya, Marcela Priotto, Marcelo Barbeito, Claudio Gobello, Cristina |
author_sort | Ponchon, Tamara |
collection | PubMed |
description | To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm(2) of endometrium nor in the height of the uterine epithelium. |
format | Online Article Text |
id | pubmed-4808635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48086352016-04-05 Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs Ponchon, Tamara Lopez Merlo, Mariana Faya, Marcela Priotto, Marcelo Barbeito, Claudio Gobello, Cristina J Vet Sci Short Communication To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm(2) of endometrium nor in the height of the uterine epithelium. The Korean Society of Veterinary Science 2016-03 2016-03-22 /pmc/articles/PMC4808635/ /pubmed/27051347 http://dx.doi.org/10.4142/jvs.2016.17.1.111 Text en © 2016 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Ponchon, Tamara Lopez Merlo, Mariana Faya, Marcela Priotto, Marcelo Barbeito, Claudio Gobello, Cristina Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs |
title | Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs |
title_full | Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs |
title_fullStr | Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs |
title_full_unstemmed | Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs |
title_short | Postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs |
title_sort | postnatal exposure to a progestin does not prevent uterine adenogenesis in domestic dogs |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808635/ https://www.ncbi.nlm.nih.gov/pubmed/27051347 http://dx.doi.org/10.4142/jvs.2016.17.1.111 |
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