Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats

We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extr...

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Detalles Bibliográficos
Autores principales: Chung, Hyo-jin, Chung, Wook-hun, Lee, Jae-Hoon, Chung, Dai-Jung, Yang, Wo-Jong, Lee, A-Jin, Choi, Chi-Bong, Chang, Hwa-Seok, Kim, Dae-Hyun, Suh, Hyun Jung, Lee, Dong-Hun, Hwang, Soo-Han, Do, Sun Hee, Kim, Hwi-Yool
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808649/
https://www.ncbi.nlm.nih.gov/pubmed/27051345
http://dx.doi.org/10.4142/jvs.2016.17.1.97
Descripción
Sumario:We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.

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