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Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung
NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808753/ https://www.ncbi.nlm.nih.gov/pubmed/26797643 http://dx.doi.org/10.3390/antiox5010004 |
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author | Horie, Masanori Yoshiura, Yukiko Izumi, Hiroto Oyabu, Takako Tomonaga, Taisuke Okada, Takami Lee, Byeong-Woo Myojo, Toshihiko Kubo, Masaru Shimada, Manabu Morimoto, Yasuo |
author_facet | Horie, Masanori Yoshiura, Yukiko Izumi, Hiroto Oyabu, Takako Tomonaga, Taisuke Okada, Takami Lee, Byeong-Woo Myojo, Toshihiko Kubo, Masaru Shimada, Manabu Morimoto, Yasuo |
author_sort | Horie, Masanori |
collection | PubMed |
description | NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative stress. The oxidative stress response protein, heme oxygenase-1 (HO-1), was induced by the administration of NiO nanoparticles at both the protein and gene expression level. Additionally, certain oxidative-stress markers in the lung, such as 8-iso-prostaglandin F2α, thioredoxin, and inducible nitric oxide synthase were increased. Furthermore, the concentration of myeloperoxidase (MPO) in the lung was also increased by the administration of NiO nanoparticles. When the amount of NiO in the lung is similar, the responses against pulmonary oxidative stress of intratracheal instillation and inhalation are also similar. However, the state of pulmonary oxidative stress in the early phase was different between intratracheal instillation and inhalation, even if the amount of NiO in the lung was similar. Inhalation causes milder oxidative stress than that caused by intratracheal instillation. On evaluation of the nanoparticle-induced pulmonary oxidative stress in the early phase, we should understand the different states of oxidative stress induced by intratracheal instillation and inhalation. |
format | Online Article Text |
id | pubmed-4808753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48087532016-04-04 Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung Horie, Masanori Yoshiura, Yukiko Izumi, Hiroto Oyabu, Takako Tomonaga, Taisuke Okada, Takami Lee, Byeong-Woo Myojo, Toshihiko Kubo, Masaru Shimada, Manabu Morimoto, Yasuo Antioxidants (Basel) Article NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative stress. The oxidative stress response protein, heme oxygenase-1 (HO-1), was induced by the administration of NiO nanoparticles at both the protein and gene expression level. Additionally, certain oxidative-stress markers in the lung, such as 8-iso-prostaglandin F2α, thioredoxin, and inducible nitric oxide synthase were increased. Furthermore, the concentration of myeloperoxidase (MPO) in the lung was also increased by the administration of NiO nanoparticles. When the amount of NiO in the lung is similar, the responses against pulmonary oxidative stress of intratracheal instillation and inhalation are also similar. However, the state of pulmonary oxidative stress in the early phase was different between intratracheal instillation and inhalation, even if the amount of NiO in the lung was similar. Inhalation causes milder oxidative stress than that caused by intratracheal instillation. On evaluation of the nanoparticle-induced pulmonary oxidative stress in the early phase, we should understand the different states of oxidative stress induced by intratracheal instillation and inhalation. MDPI 2016-01-18 /pmc/articles/PMC4808753/ /pubmed/26797643 http://dx.doi.org/10.3390/antiox5010004 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Horie, Masanori Yoshiura, Yukiko Izumi, Hiroto Oyabu, Takako Tomonaga, Taisuke Okada, Takami Lee, Byeong-Woo Myojo, Toshihiko Kubo, Masaru Shimada, Manabu Morimoto, Yasuo Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung |
title | Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung |
title_full | Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung |
title_fullStr | Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung |
title_full_unstemmed | Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung |
title_short | Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung |
title_sort | comparison of the pulmonary oxidative stress caused by intratracheal instillation and inhalation of nio nanoparticles when equivalent amounts of nio are retained in the lung |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808753/ https://www.ncbi.nlm.nih.gov/pubmed/26797643 http://dx.doi.org/10.3390/antiox5010004 |
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