Cargando…
Nuclear Tau and Its Potential Role in Alzheimer’s Disease
Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD). For nearly four decades, research efforts have focused more on tau’s role in physiology and pathology in the context of the microtubules, even th...
Autores principales: | Bukar Maina, Mahmoud, Al-Hilaly, Youssra K., Serpell, Louise C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808803/ https://www.ncbi.nlm.nih.gov/pubmed/26751496 http://dx.doi.org/10.3390/biom6010009 |
Ejemplares similares
-
Dityrosine cross-linking and its potential roles in Alzheimer’s disease
por: Maina, Mahmoud B., et al.
Publicado: (2023) -
Shapeshifting tau: from intrinsically disordered to paired-helical filaments
por: Mengham, Kurtis, et al.
Publicado: (2022) -
Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target
por: Oakley, Sebastian S., et al.
Publicado: (2020) -
Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
por: Maina, Mahmoud B., et al.
Publicado: (2021) -
Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity
por: Maina, Mahmoud B., et al.
Publicado: (2020)