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A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes
The effect of a raised body mass index (BMI) on the outcome of assisted reproduction technology (ART) still represents a controversial issue. Even less clear is whether BMI acts with a potential detrimental effect on IVF outcomes via a deleterious effect on innate quality of oocytes or on the enviro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808839/ https://www.ncbi.nlm.nih.gov/pubmed/26907340 http://dx.doi.org/10.3390/nu8030109 |
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author | Sarais, Veronica Pagliardini, Luca Rebonato, Giorgia Papaleo, Enrico Candiani, Massimo Viganò, Paola |
author_facet | Sarais, Veronica Pagliardini, Luca Rebonato, Giorgia Papaleo, Enrico Candiani, Massimo Viganò, Paola |
author_sort | Sarais, Veronica |
collection | PubMed |
description | The effect of a raised body mass index (BMI) on the outcome of assisted reproduction technology (ART) still represents a controversial issue. Even less clear is whether BMI acts with a potential detrimental effect on IVF outcomes via a deleterious effect on innate quality of oocytes or on the environmental milieu within the uterus. With the aim to better understand the mechanisms underlying the potential deleterious effect of an increased BMI on IVF outcomes, we have evaluated the effects of female BMI on number and quality of retrieved oocytes, fertilization rate, embryo score and incidences of ongoing pregnancy and live births among couples undergoing IVF in an Italian population. Data from 1602 women who underwent their first IVF cycle were retrospectively analyzed. A significantly reduced percentage of mature oocytes when comparing obese (BMI ≥ 30 kg/m(2)) and normal-weight patients (BMI = 18.50–24.99 kg/m(2)) was found. After adjusting for maternal age and other confounders, odds for ongoing pregnancy rate showed no differences across different BMI categories. However, a significant increased odds ratio (OR) could be observed for miscarriage rate in patients with BMI ≥ 25 (OR = 2.5; p = 0.04). These results should be taken into account in order to define optimal strategies for overweight and obese patients referring to ART procedures. |
format | Online Article Text |
id | pubmed-4808839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48088392016-04-04 A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes Sarais, Veronica Pagliardini, Luca Rebonato, Giorgia Papaleo, Enrico Candiani, Massimo Viganò, Paola Nutrients Article The effect of a raised body mass index (BMI) on the outcome of assisted reproduction technology (ART) still represents a controversial issue. Even less clear is whether BMI acts with a potential detrimental effect on IVF outcomes via a deleterious effect on innate quality of oocytes or on the environmental milieu within the uterus. With the aim to better understand the mechanisms underlying the potential deleterious effect of an increased BMI on IVF outcomes, we have evaluated the effects of female BMI on number and quality of retrieved oocytes, fertilization rate, embryo score and incidences of ongoing pregnancy and live births among couples undergoing IVF in an Italian population. Data from 1602 women who underwent their first IVF cycle were retrospectively analyzed. A significantly reduced percentage of mature oocytes when comparing obese (BMI ≥ 30 kg/m(2)) and normal-weight patients (BMI = 18.50–24.99 kg/m(2)) was found. After adjusting for maternal age and other confounders, odds for ongoing pregnancy rate showed no differences across different BMI categories. However, a significant increased odds ratio (OR) could be observed for miscarriage rate in patients with BMI ≥ 25 (OR = 2.5; p = 0.04). These results should be taken into account in order to define optimal strategies for overweight and obese patients referring to ART procedures. MDPI 2016-02-23 /pmc/articles/PMC4808839/ /pubmed/26907340 http://dx.doi.org/10.3390/nu8030109 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sarais, Veronica Pagliardini, Luca Rebonato, Giorgia Papaleo, Enrico Candiani, Massimo Viganò, Paola A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes |
title | A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes |
title_full | A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes |
title_fullStr | A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes |
title_full_unstemmed | A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes |
title_short | A Comprehensive Analysis of Body Mass Index Effect on in Vitro Fertilization Outcomes |
title_sort | comprehensive analysis of body mass index effect on in vitro fertilization outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808839/ https://www.ncbi.nlm.nih.gov/pubmed/26907340 http://dx.doi.org/10.3390/nu8030109 |
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