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Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic

Malnutrition has been associated with increased morbidity and mortality. The objective of this study was to determine the nutritional status and micronutrient levels of hospitalized patients in an infectious disease clinic and investigate their association with adverse clinical outcomes. The nutriti...

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Autores principales: Dizdar, Oguzhan Sıtkı, Baspınar, Osman, Kocer, Derya, Dursun, Zehra Bestepe, Avcı, Deniz, Karakükcü, Cigdem, Çelik, İlhami, Gundogan, Kursat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808854/
https://www.ncbi.nlm.nih.gov/pubmed/26938553
http://dx.doi.org/10.3390/nu8030124
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author Dizdar, Oguzhan Sıtkı
Baspınar, Osman
Kocer, Derya
Dursun, Zehra Bestepe
Avcı, Deniz
Karakükcü, Cigdem
Çelik, İlhami
Gundogan, Kursat
author_facet Dizdar, Oguzhan Sıtkı
Baspınar, Osman
Kocer, Derya
Dursun, Zehra Bestepe
Avcı, Deniz
Karakükcü, Cigdem
Çelik, İlhami
Gundogan, Kursat
author_sort Dizdar, Oguzhan Sıtkı
collection PubMed
description Malnutrition has been associated with increased morbidity and mortality. The objective of this study was to determine the nutritional status and micronutrient levels of hospitalized patients in an infectious disease clinic and investigate their association with adverse clinical outcomes. The nutritional status of the study participants was assessed using the Nutritional Risk Screening 2002 (NRS 2002) and micronutrient levels and routine biochemical parameters were tested within the first 24 h of the patient’s admission. The incidence of zinc, selenium, thiamine, vitamin B6, vitamin B12 deficiency were 66.7% (n = 40), 46.6% (n = 29), 39.7% (n = 27), 35.3% (n = 24), 14.1% (n = 9), respectively. Selenium levels were significantly higher in patients with urinary tract infections, but lower in soft tissue infections. Copper levels were significantly higher in patients with soft tissue infections. In the Cox regression models, lower albumin, higher serum lactate dehydrogenase levels and higher NRS-2002 scores were associated with increased death. Thiamine, selenium, zinc and vitamin B6 deficiencies but not chromium deficiencies are common in infectious disease clinics. New associations were found between micronutrient levels and infection type and their adverse clinical outcomes. Hypoalbuminemia and a high NRS-2002 score had the greatest accuracy in predicting death, systemic inflammatory response syndrome and sepsis on admission.
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spelling pubmed-48088542016-04-04 Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic Dizdar, Oguzhan Sıtkı Baspınar, Osman Kocer, Derya Dursun, Zehra Bestepe Avcı, Deniz Karakükcü, Cigdem Çelik, İlhami Gundogan, Kursat Nutrients Article Malnutrition has been associated with increased morbidity and mortality. The objective of this study was to determine the nutritional status and micronutrient levels of hospitalized patients in an infectious disease clinic and investigate their association with adverse clinical outcomes. The nutritional status of the study participants was assessed using the Nutritional Risk Screening 2002 (NRS 2002) and micronutrient levels and routine biochemical parameters were tested within the first 24 h of the patient’s admission. The incidence of zinc, selenium, thiamine, vitamin B6, vitamin B12 deficiency were 66.7% (n = 40), 46.6% (n = 29), 39.7% (n = 27), 35.3% (n = 24), 14.1% (n = 9), respectively. Selenium levels were significantly higher in patients with urinary tract infections, but lower in soft tissue infections. Copper levels were significantly higher in patients with soft tissue infections. In the Cox regression models, lower albumin, higher serum lactate dehydrogenase levels and higher NRS-2002 scores were associated with increased death. Thiamine, selenium, zinc and vitamin B6 deficiencies but not chromium deficiencies are common in infectious disease clinics. New associations were found between micronutrient levels and infection type and their adverse clinical outcomes. Hypoalbuminemia and a high NRS-2002 score had the greatest accuracy in predicting death, systemic inflammatory response syndrome and sepsis on admission. MDPI 2016-02-29 /pmc/articles/PMC4808854/ /pubmed/26938553 http://dx.doi.org/10.3390/nu8030124 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dizdar, Oguzhan Sıtkı
Baspınar, Osman
Kocer, Derya
Dursun, Zehra Bestepe
Avcı, Deniz
Karakükcü, Cigdem
Çelik, İlhami
Gundogan, Kursat
Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic
title Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic
title_full Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic
title_fullStr Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic
title_full_unstemmed Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic
title_short Nutritional Risk, Micronutrient Status and Clinical Outcomes: A Prospective Observational Study in an Infectious Disease Clinic
title_sort nutritional risk, micronutrient status and clinical outcomes: a prospective observational study in an infectious disease clinic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808854/
https://www.ncbi.nlm.nih.gov/pubmed/26938553
http://dx.doi.org/10.3390/nu8030124
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