Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway

Deer antler preparations have been used to strengthen bones for centuries. It is particularly rich in collagen type I. This study aimed to unravel part of the purported bioremedial effect of Sika deer antler collagen type I (SDA-Col I) on bone marrow mesenchymal stem cells. The results suggest that...

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Detalles Bibliográficos
Autores principales: Li, Na, Zhang, Min, Drummen, Gregor P. C., Zhao, Yu, Tan, Yin Fen, Luo, Su, Qu, Xiao Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809101/
https://www.ncbi.nlm.nih.gov/pubmed/27066099
http://dx.doi.org/10.1155/2016/2109204
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author Li, Na
Zhang, Min
Drummen, Gregor P. C.
Zhao, Yu
Tan, Yin Fen
Luo, Su
Qu, Xiao Bo
author_facet Li, Na
Zhang, Min
Drummen, Gregor P. C.
Zhao, Yu
Tan, Yin Fen
Luo, Su
Qu, Xiao Bo
author_sort Li, Na
collection PubMed
description Deer antler preparations have been used to strengthen bones for centuries. It is particularly rich in collagen type I. This study aimed to unravel part of the purported bioremedial effect of Sika deer antler collagen type I (SDA-Col I) on bone marrow mesenchymal stem cells. The results suggest that SDA-Col I might be used to promote and regulate osteoblast proliferation and differentiation. SDA-Col I might potentially provide the basis for novel therapeutic strategies in the treatment of bone injury and/or in scaffolds for bone replacement strategies. Finally, isolation of SDA-Col I from deer antler represents a renewable, green, and uncomplicated way to obtain a biomedically valuable therapeutic.
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spelling pubmed-48091012016-04-10 Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway Li, Na Zhang, Min Drummen, Gregor P. C. Zhao, Yu Tan, Yin Fen Luo, Su Qu, Xiao Bo Evid Based Complement Alternat Med Research Article Deer antler preparations have been used to strengthen bones for centuries. It is particularly rich in collagen type I. This study aimed to unravel part of the purported bioremedial effect of Sika deer antler collagen type I (SDA-Col I) on bone marrow mesenchymal stem cells. The results suggest that SDA-Col I might be used to promote and regulate osteoblast proliferation and differentiation. SDA-Col I might potentially provide the basis for novel therapeutic strategies in the treatment of bone injury and/or in scaffolds for bone replacement strategies. Finally, isolation of SDA-Col I from deer antler represents a renewable, green, and uncomplicated way to obtain a biomedically valuable therapeutic. Hindawi Publishing Corporation 2016 2016-01-04 /pmc/articles/PMC4809101/ /pubmed/27066099 http://dx.doi.org/10.1155/2016/2109204 Text en Copyright © 2016 Na Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Na
Zhang, Min
Drummen, Gregor P. C.
Zhao, Yu
Tan, Yin Fen
Luo, Su
Qu, Xiao Bo
Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
title Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
title_full Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
title_fullStr Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
title_full_unstemmed Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
title_short Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
title_sort sika deer antler collagen type i-accelerated osteogenesis in bone marrow mesenchymal stem cells via the smad pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809101/
https://www.ncbi.nlm.nih.gov/pubmed/27066099
http://dx.doi.org/10.1155/2016/2109204
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