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Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules

BACKGROUND: Sonoelastography is a new ultrasound method which could be helpful to determine which thyroid nodule is malignant. We designed this study to evaluate the accuracy of sonoelastography in differentiating of benign and malignant thyroid nodules in Iranian patients. METHODS: Forty thyroid no...

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Autores principales: Esfahanian, Fatemeh, Aryan, Arvin, Ghajarzadeh, Mahsa, Yazdi, Meisam Hosein, Nobakht, Nasir, Burchi, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809115/
https://www.ncbi.nlm.nih.gov/pubmed/27076893
http://dx.doi.org/10.4103/2008-7802.178355
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author Esfahanian, Fatemeh
Aryan, Arvin
Ghajarzadeh, Mahsa
Yazdi, Meisam Hosein
Nobakht, Nasir
Burchi, Mehdi
author_facet Esfahanian, Fatemeh
Aryan, Arvin
Ghajarzadeh, Mahsa
Yazdi, Meisam Hosein
Nobakht, Nasir
Burchi, Mehdi
author_sort Esfahanian, Fatemeh
collection PubMed
description BACKGROUND: Sonoelastography is a new ultrasound method which could be helpful to determine which thyroid nodule is malignant. We designed this study to evaluate the accuracy of sonoelastography in differentiating of benign and malignant thyroid nodules in Iranian patients. METHODS: Forty thyroid nodules in forty consecutive patients who had been referred for sonography-guided fine-needle aspiration biopsy were evaluated. Gray scale ultrasound and elastosonography by real-time, freehand technique applied for all patients. Elastography findings were classified into four groups. Nodules which were classified as patterns 1 or 2 in elastogram evaluation were classified as benign and probably malignant if elastogram scans were patterns 3 and 4 of elastogram scan. RESULTS: Mean age ± standard deviation (SD) was 42.2 ± 12.6 years, and mean ± SD thyroid-stimulating hormone level was 1.4 ± 1.9 IU/ml. Thirty-five cases (87.5%) were female and 5 (12.5%) were male. Histological examination indicated 27 (67.5%) benign and 13 (32.5%) malignant nodules. The most elastogram score was 2 (50%) followed by score 3. The cut-off point of 2 considered as the best value to differentiate benign and malignant thyroid nodules with sensitivity and specificity of 61% and 78% (area under the curve = 0.76, 95% confidence interval: 0.6–0.92, P = 0.007). CONCLUSIONS: Sonoelastography could help to differentiate benign and malignant thyroid nodules. As our sample size was limited, larger studies are recommended.
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spelling pubmed-48091152016-04-13 Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules Esfahanian, Fatemeh Aryan, Arvin Ghajarzadeh, Mahsa Yazdi, Meisam Hosein Nobakht, Nasir Burchi, Mehdi Int J Prev Med Original Article BACKGROUND: Sonoelastography is a new ultrasound method which could be helpful to determine which thyroid nodule is malignant. We designed this study to evaluate the accuracy of sonoelastography in differentiating of benign and malignant thyroid nodules in Iranian patients. METHODS: Forty thyroid nodules in forty consecutive patients who had been referred for sonography-guided fine-needle aspiration biopsy were evaluated. Gray scale ultrasound and elastosonography by real-time, freehand technique applied for all patients. Elastography findings were classified into four groups. Nodules which were classified as patterns 1 or 2 in elastogram evaluation were classified as benign and probably malignant if elastogram scans were patterns 3 and 4 of elastogram scan. RESULTS: Mean age ± standard deviation (SD) was 42.2 ± 12.6 years, and mean ± SD thyroid-stimulating hormone level was 1.4 ± 1.9 IU/ml. Thirty-five cases (87.5%) were female and 5 (12.5%) were male. Histological examination indicated 27 (67.5%) benign and 13 (32.5%) malignant nodules. The most elastogram score was 2 (50%) followed by score 3. The cut-off point of 2 considered as the best value to differentiate benign and malignant thyroid nodules with sensitivity and specificity of 61% and 78% (area under the curve = 0.76, 95% confidence interval: 0.6–0.92, P = 0.007). CONCLUSIONS: Sonoelastography could help to differentiate benign and malignant thyroid nodules. As our sample size was limited, larger studies are recommended. Medknow Publications & Media Pvt Ltd 2016-03-09 /pmc/articles/PMC4809115/ /pubmed/27076893 http://dx.doi.org/10.4103/2008-7802.178355 Text en Copyright: © 2016 International Journal of Preventive Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Esfahanian, Fatemeh
Aryan, Arvin
Ghajarzadeh, Mahsa
Yazdi, Meisam Hosein
Nobakht, Nasir
Burchi, Mehdi
Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules
title Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules
title_full Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules
title_fullStr Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules
title_full_unstemmed Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules
title_short Application of Sonoelastography in Differential Diagnosis of Benign and Malignant Thyroid Nodules
title_sort application of sonoelastography in differential diagnosis of benign and malignant thyroid nodules
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809115/
https://www.ncbi.nlm.nih.gov/pubmed/27076893
http://dx.doi.org/10.4103/2008-7802.178355
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