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Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study

BACKGROUND: Risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), may be increased in liver cirrhosis. We conducted a single-center study to explore the epidemiology, risk factors, and in-hospital mortality of VTE in Chinese patients with liver cirrh...

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Autores principales: Zhang, Xintong, Qi, Xingshun, De Stefano, Valerio, Hou, Feifei, Ning, Zheng, Zhao, Jiancheng, Peng, Ying, Li, Jing, Deng, Han, Li, Hongyu, Guo, Xiaozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809389/
https://www.ncbi.nlm.nih.gov/pubmed/27009380
http://dx.doi.org/10.12659/MSM.896153
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author Zhang, Xintong
Qi, Xingshun
De Stefano, Valerio
Hou, Feifei
Ning, Zheng
Zhao, Jiancheng
Peng, Ying
Li, Jing
Deng, Han
Li, Hongyu
Guo, Xiaozhong
author_facet Zhang, Xintong
Qi, Xingshun
De Stefano, Valerio
Hou, Feifei
Ning, Zheng
Zhao, Jiancheng
Peng, Ying
Li, Jing
Deng, Han
Li, Hongyu
Guo, Xiaozhong
author_sort Zhang, Xintong
collection PubMed
description BACKGROUND: Risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), may be increased in liver cirrhosis. We conducted a single-center study to explore the epidemiology, risk factors, and in-hospital mortality of VTE in Chinese patients with liver cirrhosis. MATERIAL/METHODS: All patients with liver cirrhosis who were consecutively admitted to our hospital between January 2011 and December 2013 were retrospectively included. RESULTS: Of 2006 patients with liver cirrhosis included, 9 patients were diagnosed with or developed VTE during hospitalization, including 5 patients with a previous history of DVT, 1 patient with either a previous history of DVT or new onset of PE, and 3 patients with new onset of VTE (PE, n=1; DVT, n=2). Risk factors for VTE included a significantly higher proportion of hypertension and significantly higher red blood cells, hemoglobin, alanine aminotransferase, aspartate aminotransferase, prothrombin time (PT), international normalized ratio (INR), D-dimer, and Child-Pugh scores. The in-hospital mortality was significantly higher in patients with VTE than those without VTE (33.3% [3/9] versus 3.4% [67/1997], P<0.001). CONCLUSIONS: VTE was observed in 0.4% of patients with liver cirrhosis during hospitalization and it significantly increased the in-hospital mortality. Elevated PT/INR aggravated the risk of VTE.
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spelling pubmed-48093892016-04-08 Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study Zhang, Xintong Qi, Xingshun De Stefano, Valerio Hou, Feifei Ning, Zheng Zhao, Jiancheng Peng, Ying Li, Jing Deng, Han Li, Hongyu Guo, Xiaozhong Med Sci Monit Clinical Research BACKGROUND: Risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), may be increased in liver cirrhosis. We conducted a single-center study to explore the epidemiology, risk factors, and in-hospital mortality of VTE in Chinese patients with liver cirrhosis. MATERIAL/METHODS: All patients with liver cirrhosis who were consecutively admitted to our hospital between January 2011 and December 2013 were retrospectively included. RESULTS: Of 2006 patients with liver cirrhosis included, 9 patients were diagnosed with or developed VTE during hospitalization, including 5 patients with a previous history of DVT, 1 patient with either a previous history of DVT or new onset of PE, and 3 patients with new onset of VTE (PE, n=1; DVT, n=2). Risk factors for VTE included a significantly higher proportion of hypertension and significantly higher red blood cells, hemoglobin, alanine aminotransferase, aspartate aminotransferase, prothrombin time (PT), international normalized ratio (INR), D-dimer, and Child-Pugh scores. The in-hospital mortality was significantly higher in patients with VTE than those without VTE (33.3% [3/9] versus 3.4% [67/1997], P<0.001). CONCLUSIONS: VTE was observed in 0.4% of patients with liver cirrhosis during hospitalization and it significantly increased the in-hospital mortality. Elevated PT/INR aggravated the risk of VTE. International Scientific Literature, Inc. 2016-03-24 /pmc/articles/PMC4809389/ /pubmed/27009380 http://dx.doi.org/10.12659/MSM.896153 Text en © Med Sci Monit, 2016 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Zhang, Xintong
Qi, Xingshun
De Stefano, Valerio
Hou, Feifei
Ning, Zheng
Zhao, Jiancheng
Peng, Ying
Li, Jing
Deng, Han
Li, Hongyu
Guo, Xiaozhong
Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study
title Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study
title_full Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study
title_fullStr Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study
title_full_unstemmed Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study
title_short Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study
title_sort epidemiology, risk factors, and in-hospital mortality of venous thromboembolism in liver cirrhosis: a single-center retrospective observational study
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809389/
https://www.ncbi.nlm.nih.gov/pubmed/27009380
http://dx.doi.org/10.12659/MSM.896153
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