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Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe

BACKGROUND: More than half of malaria cases in Zimbabwe are concentrated in Manicaland Province, where seasonal malaria epidemics occur despite intensified control strategies. Recently, high levels of pyrethroid and carbamate resistance were detected in Anopheles funestus, the major malaria vector i...

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Autores principales: Kanyangarara, Mufaro, Mamini, Edmore, Mharakurwa, Sungano, Munyati, Shungu, Gwanzura, Lovemore, Kobayashi, Tamaki, Shields, Timothy, Mullany, Luke C., Mutambu, Susan, Mason, Peter R., Curriero, Frank C., Moss, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809594/
https://www.ncbi.nlm.nih.gov/pubmed/27018893
http://dx.doi.org/10.1371/journal.pone.0151971
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author Kanyangarara, Mufaro
Mamini, Edmore
Mharakurwa, Sungano
Munyati, Shungu
Gwanzura, Lovemore
Kobayashi, Tamaki
Shields, Timothy
Mullany, Luke C.
Mutambu, Susan
Mason, Peter R.
Curriero, Frank C.
Moss, William J.
author_facet Kanyangarara, Mufaro
Mamini, Edmore
Mharakurwa, Sungano
Munyati, Shungu
Gwanzura, Lovemore
Kobayashi, Tamaki
Shields, Timothy
Mullany, Luke C.
Mutambu, Susan
Mason, Peter R.
Curriero, Frank C.
Moss, William J.
author_sort Kanyangarara, Mufaro
collection PubMed
description BACKGROUND: More than half of malaria cases in Zimbabwe are concentrated in Manicaland Province, where seasonal malaria epidemics occur despite intensified control strategies. Recently, high levels of pyrethroid and carbamate resistance were detected in Anopheles funestus, the major malaria vector in eastern Zimbabwe. In response, a single round of indoor residual spraying (IRS) using pirimiphos-methyl (an organophosphate) was implemented in four high burden districts of Manicaland Province from November 1, 2014 to December 19, 2014. The objective of this study was to evaluate the effect of this programmatic switch in insecticides on malaria morbidity reported from health care facilities in Mutasa District, one of the worst affected districts in Manicaland Province. METHODS: The number of weekly malaria cases for each health facility 24 months prior to the 2014 IRS campaign and in the subsequent high transmission season were obtained from passive case surveillance. Environmental variables were extracted from remote-sensing data sources and linked to each health care facility. Negative binomial regression was used to model the weekly number of malaria cases, adjusted for seasonality and environmental variables. RESULTS: From December 2012 to May 2015, 124,206 malaria cases were reported from 42 health care facilities in Mutasa District. Based on a higher burden of malaria, 20 out of 31 municipal wards were sprayed in the district. Overall, 87.3% of target structures were sprayed and 92.1% of the target population protected. During the 6 months after the 2014 IRS campaign, a period when transmission would have otherwise peaked, the incidence of malaria was 38% lower than the preceding 24 months at health facilities in the sprayed wards. CONCLUSIONS: Pirimiphos-methyl had a measurable impact on malaria incidence and is an effective insecticide for the control of An. funestus in eastern Zimbabwe.
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spelling pubmed-48095942016-04-05 Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe Kanyangarara, Mufaro Mamini, Edmore Mharakurwa, Sungano Munyati, Shungu Gwanzura, Lovemore Kobayashi, Tamaki Shields, Timothy Mullany, Luke C. Mutambu, Susan Mason, Peter R. Curriero, Frank C. Moss, William J. PLoS One Research Article BACKGROUND: More than half of malaria cases in Zimbabwe are concentrated in Manicaland Province, where seasonal malaria epidemics occur despite intensified control strategies. Recently, high levels of pyrethroid and carbamate resistance were detected in Anopheles funestus, the major malaria vector in eastern Zimbabwe. In response, a single round of indoor residual spraying (IRS) using pirimiphos-methyl (an organophosphate) was implemented in four high burden districts of Manicaland Province from November 1, 2014 to December 19, 2014. The objective of this study was to evaluate the effect of this programmatic switch in insecticides on malaria morbidity reported from health care facilities in Mutasa District, one of the worst affected districts in Manicaland Province. METHODS: The number of weekly malaria cases for each health facility 24 months prior to the 2014 IRS campaign and in the subsequent high transmission season were obtained from passive case surveillance. Environmental variables were extracted from remote-sensing data sources and linked to each health care facility. Negative binomial regression was used to model the weekly number of malaria cases, adjusted for seasonality and environmental variables. RESULTS: From December 2012 to May 2015, 124,206 malaria cases were reported from 42 health care facilities in Mutasa District. Based on a higher burden of malaria, 20 out of 31 municipal wards were sprayed in the district. Overall, 87.3% of target structures were sprayed and 92.1% of the target population protected. During the 6 months after the 2014 IRS campaign, a period when transmission would have otherwise peaked, the incidence of malaria was 38% lower than the preceding 24 months at health facilities in the sprayed wards. CONCLUSIONS: Pirimiphos-methyl had a measurable impact on malaria incidence and is an effective insecticide for the control of An. funestus in eastern Zimbabwe. Public Library of Science 2016-03-28 /pmc/articles/PMC4809594/ /pubmed/27018893 http://dx.doi.org/10.1371/journal.pone.0151971 Text en © 2016 Kanyangarara et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kanyangarara, Mufaro
Mamini, Edmore
Mharakurwa, Sungano
Munyati, Shungu
Gwanzura, Lovemore
Kobayashi, Tamaki
Shields, Timothy
Mullany, Luke C.
Mutambu, Susan
Mason, Peter R.
Curriero, Frank C.
Moss, William J.
Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe
title Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe
title_full Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe
title_fullStr Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe
title_full_unstemmed Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe
title_short Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe
title_sort reduction in malaria incidence following indoor residual spraying with actellic 300 cs in a setting with pyrethroid resistance: mutasa district, zimbabwe
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809594/
https://www.ncbi.nlm.nih.gov/pubmed/27018893
http://dx.doi.org/10.1371/journal.pone.0151971
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