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Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes
The trophic peptide hormone adrenocorticotropic (ACTH) stimulates steroid hormone biosynthesis evoking both a rapid, acute response and a long-term, chronic response, via the activation of cAMP/protein kinase A (PKA) signaling. The acute response is initiated by the mobilization of cholesterol from...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810002/ https://www.ncbi.nlm.nih.gov/pubmed/27065945 http://dx.doi.org/10.3389/fendo.2016.00024 |
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author | Ruggiero, Carmen Lalli, Enzo |
author_facet | Ruggiero, Carmen Lalli, Enzo |
author_sort | Ruggiero, Carmen |
collection | PubMed |
description | The trophic peptide hormone adrenocorticotropic (ACTH) stimulates steroid hormone biosynthesis evoking both a rapid, acute response and a long-term, chronic response, via the activation of cAMP/protein kinase A (PKA) signaling. The acute response is initiated by the mobilization of cholesterol from lipid stores and its delivery to the inner mitochondrial membrane, a process that is mediated by the steroidogenic acute regulatory protein. The chronic response results in the increased coordinated transcription of genes encoding steroidogenic enzymes. ACTH binding to its cognate receptor, melanocortin 2 receptor (MC2R), stimulates adenylyl cyclase, thus inducing cAMP production, PKA activation, and phosphorylation of specific nuclear factors, which bind to target promoters and facilitate coactivator protein recruitment to direct steroidogenic gene transcription. This review provides a general view of the transcriptional control exerted by the ACTH/cAMP system on the expression of genes encoding for steroidogenic enzymes in the adrenal cortex. Special emphasis will be given to the transcription factors required to mediate ACTH-dependent transcription of steroidogenic genes. |
format | Online Article Text |
id | pubmed-4810002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48100022016-04-08 Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes Ruggiero, Carmen Lalli, Enzo Front Endocrinol (Lausanne) Endocrinology The trophic peptide hormone adrenocorticotropic (ACTH) stimulates steroid hormone biosynthesis evoking both a rapid, acute response and a long-term, chronic response, via the activation of cAMP/protein kinase A (PKA) signaling. The acute response is initiated by the mobilization of cholesterol from lipid stores and its delivery to the inner mitochondrial membrane, a process that is mediated by the steroidogenic acute regulatory protein. The chronic response results in the increased coordinated transcription of genes encoding steroidogenic enzymes. ACTH binding to its cognate receptor, melanocortin 2 receptor (MC2R), stimulates adenylyl cyclase, thus inducing cAMP production, PKA activation, and phosphorylation of specific nuclear factors, which bind to target promoters and facilitate coactivator protein recruitment to direct steroidogenic gene transcription. This review provides a general view of the transcriptional control exerted by the ACTH/cAMP system on the expression of genes encoding for steroidogenic enzymes in the adrenal cortex. Special emphasis will be given to the transcription factors required to mediate ACTH-dependent transcription of steroidogenic genes. Frontiers Media S.A. 2016-03-29 /pmc/articles/PMC4810002/ /pubmed/27065945 http://dx.doi.org/10.3389/fendo.2016.00024 Text en Copyright © 2016 Ruggiero and Lalli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Ruggiero, Carmen Lalli, Enzo Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes |
title | Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes |
title_full | Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes |
title_fullStr | Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes |
title_full_unstemmed | Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes |
title_short | Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes |
title_sort | impact of acth signaling on transcriptional regulation of steroidogenic genes |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810002/ https://www.ncbi.nlm.nih.gov/pubmed/27065945 http://dx.doi.org/10.3389/fendo.2016.00024 |
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