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Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy

Myosin-binding protein C (MyBPC) in the muscle sarcomere interacts with several contractile and structural proteins. Mutations in the cardiac isoform (MyBPC-3) in humans, or animal knockout, are associated with cardiomyopathy. Function of the fast skeletal isoform (MyBPC-2) in living muscles is less...

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Detalles Bibliográficos
Autores principales: Li, Mei, Andersson-Lendahl, Monika, Sejersen, Thomas, Arner, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810067/
https://www.ncbi.nlm.nih.gov/pubmed/27022191
http://dx.doi.org/10.1085/jgp.201511452