Hypoxia Induced NF-κB

As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been pr...

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Detalles Bibliográficos
Autores principales: D’Ignazio, Laura, Rocha, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810095/
https://www.ncbi.nlm.nih.gov/pubmed/27005664
http://dx.doi.org/10.3390/cells5010010
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author D’Ignazio, Laura
Rocha, Sonia
author_facet D’Ignazio, Laura
Rocha, Sonia
author_sort D’Ignazio, Laura
collection PubMed
description As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia.
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spelling pubmed-48100952016-04-04 Hypoxia Induced NF-κB D’Ignazio, Laura Rocha, Sonia Cells Review As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia. MDPI 2016-03-08 /pmc/articles/PMC4810095/ /pubmed/27005664 http://dx.doi.org/10.3390/cells5010010 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
D’Ignazio, Laura
Rocha, Sonia
Hypoxia Induced NF-κB
title Hypoxia Induced NF-κB
title_full Hypoxia Induced NF-κB
title_fullStr Hypoxia Induced NF-κB
title_full_unstemmed Hypoxia Induced NF-κB
title_short Hypoxia Induced NF-κB
title_sort hypoxia induced nf-κb
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810095/
https://www.ncbi.nlm.nih.gov/pubmed/27005664
http://dx.doi.org/10.3390/cells5010010
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