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The Regulation of NF-κB Subunits by Phosphorylation

The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental rol...

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Detalles Bibliográficos
Autores principales: Christian, Frank, Smith, Emma L., Carmody, Ruaidhrí J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810097/
https://www.ncbi.nlm.nih.gov/pubmed/26999213
http://dx.doi.org/10.3390/cells5010012
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author Christian, Frank
Smith, Emma L.
Carmody, Ruaidhrí J.
author_facet Christian, Frank
Smith, Emma L.
Carmody, Ruaidhrí J.
author_sort Christian, Frank
collection PubMed
description The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-κB in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-κB activation. However, significant research efforts have revealed the crucial contribution of NF-κB phosphorylation to controlling NF-κB directed transactivation. Importantly, NF-κB phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-κB for therapeutic benefit. This review will focus on the phosphorylation of the NF-κB subunits and the impact on NF-κB function.
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spelling pubmed-48100972016-04-04 The Regulation of NF-κB Subunits by Phosphorylation Christian, Frank Smith, Emma L. Carmody, Ruaidhrí J. Cells Review The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-κB in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-κB activation. However, significant research efforts have revealed the crucial contribution of NF-κB phosphorylation to controlling NF-κB directed transactivation. Importantly, NF-κB phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-κB for therapeutic benefit. This review will focus on the phosphorylation of the NF-κB subunits and the impact on NF-κB function. MDPI 2016-03-18 /pmc/articles/PMC4810097/ /pubmed/26999213 http://dx.doi.org/10.3390/cells5010012 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Christian, Frank
Smith, Emma L.
Carmody, Ruaidhrí J.
The Regulation of NF-κB Subunits by Phosphorylation
title The Regulation of NF-κB Subunits by Phosphorylation
title_full The Regulation of NF-κB Subunits by Phosphorylation
title_fullStr The Regulation of NF-κB Subunits by Phosphorylation
title_full_unstemmed The Regulation of NF-κB Subunits by Phosphorylation
title_short The Regulation of NF-κB Subunits by Phosphorylation
title_sort regulation of nf-κb subunits by phosphorylation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810097/
https://www.ncbi.nlm.nih.gov/pubmed/26999213
http://dx.doi.org/10.3390/cells5010012
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