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The Regulation of NF-κB Subunits by Phosphorylation
The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental rol...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810097/ https://www.ncbi.nlm.nih.gov/pubmed/26999213 http://dx.doi.org/10.3390/cells5010012 |
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author | Christian, Frank Smith, Emma L. Carmody, Ruaidhrí J. |
author_facet | Christian, Frank Smith, Emma L. Carmody, Ruaidhrí J. |
author_sort | Christian, Frank |
collection | PubMed |
description | The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-κB in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-κB activation. However, significant research efforts have revealed the crucial contribution of NF-κB phosphorylation to controlling NF-κB directed transactivation. Importantly, NF-κB phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-κB for therapeutic benefit. This review will focus on the phosphorylation of the NF-κB subunits and the impact on NF-κB function. |
format | Online Article Text |
id | pubmed-4810097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48100972016-04-04 The Regulation of NF-κB Subunits by Phosphorylation Christian, Frank Smith, Emma L. Carmody, Ruaidhrí J. Cells Review The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-κB in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-κB activation. However, significant research efforts have revealed the crucial contribution of NF-κB phosphorylation to controlling NF-κB directed transactivation. Importantly, NF-κB phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-κB for therapeutic benefit. This review will focus on the phosphorylation of the NF-κB subunits and the impact on NF-κB function. MDPI 2016-03-18 /pmc/articles/PMC4810097/ /pubmed/26999213 http://dx.doi.org/10.3390/cells5010012 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Christian, Frank Smith, Emma L. Carmody, Ruaidhrí J. The Regulation of NF-κB Subunits by Phosphorylation |
title | The Regulation of NF-κB Subunits by Phosphorylation |
title_full | The Regulation of NF-κB Subunits by Phosphorylation |
title_fullStr | The Regulation of NF-κB Subunits by Phosphorylation |
title_full_unstemmed | The Regulation of NF-κB Subunits by Phosphorylation |
title_short | The Regulation of NF-κB Subunits by Phosphorylation |
title_sort | regulation of nf-κb subunits by phosphorylation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810097/ https://www.ncbi.nlm.nih.gov/pubmed/26999213 http://dx.doi.org/10.3390/cells5010012 |
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