The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We he...

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Detalles Bibliográficos
Autores principales: Cooke Bailey, Jessica N., Hoffman, Joshua D., Sardell, Rebecca J., Scott, William K., Pericak-Vance, Margaret A., Haines, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810102/
https://www.ncbi.nlm.nih.gov/pubmed/26959068
http://dx.doi.org/10.3390/jcm5030031
Descripción
Sumario:Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.

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