The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We he...

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Autores principales: Cooke Bailey, Jessica N., Hoffman, Joshua D., Sardell, Rebecca J., Scott, William K., Pericak-Vance, Margaret A., Haines, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810102/
https://www.ncbi.nlm.nih.gov/pubmed/26959068
http://dx.doi.org/10.3390/jcm5030031
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author Cooke Bailey, Jessica N.
Hoffman, Joshua D.
Sardell, Rebecca J.
Scott, William K.
Pericak-Vance, Margaret A.
Haines, Jonathan L.
author_facet Cooke Bailey, Jessica N.
Hoffman, Joshua D.
Sardell, Rebecca J.
Scott, William K.
Pericak-Vance, Margaret A.
Haines, Jonathan L.
author_sort Cooke Bailey, Jessica N.
collection PubMed
description Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD.
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spelling pubmed-48101022016-04-04 The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review Cooke Bailey, Jessica N. Hoffman, Joshua D. Sardell, Rebecca J. Scott, William K. Pericak-Vance, Margaret A. Haines, Jonathan L. J Clin Med Review Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD. MDPI 2016-03-04 /pmc/articles/PMC4810102/ /pubmed/26959068 http://dx.doi.org/10.3390/jcm5030031 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cooke Bailey, Jessica N.
Hoffman, Joshua D.
Sardell, Rebecca J.
Scott, William K.
Pericak-Vance, Margaret A.
Haines, Jonathan L.
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
title The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
title_full The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
title_fullStr The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
title_full_unstemmed The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
title_short The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
title_sort application of genetic risk scores in age-related macular degeneration: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810102/
https://www.ncbi.nlm.nih.gov/pubmed/26959068
http://dx.doi.org/10.3390/jcm5030031
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