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Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) pla...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810109/ https://www.ncbi.nlm.nih.gov/pubmed/26999230 http://dx.doi.org/10.3390/jcm5030038 |
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author | Kitano, Mio Bloomston, P. Mark |
author_facet | Kitano, Mio Bloomston, P. Mark |
author_sort | Kitano, Mio |
collection | PubMed |
description | microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis. |
format | Online Article Text |
id | pubmed-4810109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48101092016-04-04 Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis Kitano, Mio Bloomston, P. Mark J Clin Med Review microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis. MDPI 2016-03-16 /pmc/articles/PMC4810109/ /pubmed/26999230 http://dx.doi.org/10.3390/jcm5030038 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kitano, Mio Bloomston, P. Mark Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis |
title | Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis |
title_full | Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis |
title_fullStr | Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis |
title_full_unstemmed | Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis |
title_short | Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis |
title_sort | hepatic stellate cells and micrornas in pathogenesis of liver fibrosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810109/ https://www.ncbi.nlm.nih.gov/pubmed/26999230 http://dx.doi.org/10.3390/jcm5030038 |
work_keys_str_mv | AT kitanomio hepaticstellatecellsandmicrornasinpathogenesisofliverfibrosis AT bloomstonpmark hepaticstellatecellsandmicrornasinpathogenesisofliverfibrosis |