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Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) pla...

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Detalles Bibliográficos
Autores principales: Kitano, Mio, Bloomston, P. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810109/
https://www.ncbi.nlm.nih.gov/pubmed/26999230
http://dx.doi.org/10.3390/jcm5030038
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author Kitano, Mio
Bloomston, P. Mark
author_facet Kitano, Mio
Bloomston, P. Mark
author_sort Kitano, Mio
collection PubMed
description microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis.
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spelling pubmed-48101092016-04-04 Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis Kitano, Mio Bloomston, P. Mark J Clin Med Review microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of miRNAs on their activation, proliferation, collagen production, migration, and apoptosis. There are multiple differentially expressed miRNAs in activated HSCs, and in this review we aim to summarize current data on miRNAs that participate in the development of hepatic fibrosis. Based on this review, miRNAs may serve as biomarkers for diagnosis of liver disease, as well as markers of disease progression. Most importantly, dysregulated miRNAs may potentially be targeted by novel therapies to treat and reverse progression of hepatic fibrosis. MDPI 2016-03-16 /pmc/articles/PMC4810109/ /pubmed/26999230 http://dx.doi.org/10.3390/jcm5030038 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kitano, Mio
Bloomston, P. Mark
Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
title Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
title_full Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
title_fullStr Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
title_full_unstemmed Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
title_short Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
title_sort hepatic stellate cells and micrornas in pathogenesis of liver fibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810109/
https://www.ncbi.nlm.nih.gov/pubmed/26999230
http://dx.doi.org/10.3390/jcm5030038
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