Genetic Variations in Vesicoureteral Reflux Sequelae

Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic...

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Detalles Bibliográficos
Autores principales: Hains, David S., Schwaderer, Andrew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810135/
https://www.ncbi.nlm.nih.gov/pubmed/26848692
http://dx.doi.org/10.3390/pathogens5010014
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author Hains, David S.
Schwaderer, Andrew L.
author_facet Hains, David S.
Schwaderer, Andrew L.
author_sort Hains, David S.
collection PubMed
description Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview, we discuss how current cohorts and genetic strategies can be implemented to discover new susceptibility loci in patients with UTI.
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spelling pubmed-48101352016-04-04 Genetic Variations in Vesicoureteral Reflux Sequelae Hains, David S. Schwaderer, Andrew L. Pathogens Review Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview, we discuss how current cohorts and genetic strategies can be implemented to discover new susceptibility loci in patients with UTI. MDPI 2016-02-02 /pmc/articles/PMC4810135/ /pubmed/26848692 http://dx.doi.org/10.3390/pathogens5010014 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hains, David S.
Schwaderer, Andrew L.
Genetic Variations in Vesicoureteral Reflux Sequelae
title Genetic Variations in Vesicoureteral Reflux Sequelae
title_full Genetic Variations in Vesicoureteral Reflux Sequelae
title_fullStr Genetic Variations in Vesicoureteral Reflux Sequelae
title_full_unstemmed Genetic Variations in Vesicoureteral Reflux Sequelae
title_short Genetic Variations in Vesicoureteral Reflux Sequelae
title_sort genetic variations in vesicoureteral reflux sequelae
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810135/
https://www.ncbi.nlm.nih.gov/pubmed/26848692
http://dx.doi.org/10.3390/pathogens5010014
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