Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages

The antibacterial defense against infections depends on the cooperation between distinct phagocytes of the innate immune system, namely macrophages and neutrophils. However, the mechanisms driving this cooperation are incompletely understood. In this study we describe the crosstalk between Ly6C(+) a...

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Detalles Bibliográficos
Autores principales: Zec, Kristina, Volke, Julia, Vijitha, Nirojah, Thiebes, Stephanie, Gunzer, Matthias, Kurts, Christian, Engel, Daniel Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810136/
https://www.ncbi.nlm.nih.gov/pubmed/26861402
http://dx.doi.org/10.3390/pathogens5010015
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author Zec, Kristina
Volke, Julia
Vijitha, Nirojah
Thiebes, Stephanie
Gunzer, Matthias
Kurts, Christian
Engel, Daniel Robert
author_facet Zec, Kristina
Volke, Julia
Vijitha, Nirojah
Thiebes, Stephanie
Gunzer, Matthias
Kurts, Christian
Engel, Daniel Robert
author_sort Zec, Kristina
collection PubMed
description The antibacterial defense against infections depends on the cooperation between distinct phagocytes of the innate immune system, namely macrophages and neutrophils. However, the mechanisms driving this cooperation are incompletely understood. In this study we describe the crosstalk between Ly6C(+) and Ly6C(−) macrophage-subtypes and neutrophils in the context of urinary tract infection (UTI) with uropathogenic E. coli (UPEC). Ly6C(−) macrophages acted as tissue resident sentinels and attracted circulating phagocytes by chemokines. Ly6C(+) macrophages produced tumor necrosis factor (TNF) that licensed Ly6C(−) macrophages to release preformed CXCL2, which in turn caused matrix metalloproteinases (MMP-9) secretion by neutrophils to enable transepithelial migration.
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spelling pubmed-48101362016-04-04 Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages Zec, Kristina Volke, Julia Vijitha, Nirojah Thiebes, Stephanie Gunzer, Matthias Kurts, Christian Engel, Daniel Robert Pathogens Article The antibacterial defense against infections depends on the cooperation between distinct phagocytes of the innate immune system, namely macrophages and neutrophils. However, the mechanisms driving this cooperation are incompletely understood. In this study we describe the crosstalk between Ly6C(+) and Ly6C(−) macrophage-subtypes and neutrophils in the context of urinary tract infection (UTI) with uropathogenic E. coli (UPEC). Ly6C(−) macrophages acted as tissue resident sentinels and attracted circulating phagocytes by chemokines. Ly6C(+) macrophages produced tumor necrosis factor (TNF) that licensed Ly6C(−) macrophages to release preformed CXCL2, which in turn caused matrix metalloproteinases (MMP-9) secretion by neutrophils to enable transepithelial migration. MDPI 2016-02-04 /pmc/articles/PMC4810136/ /pubmed/26861402 http://dx.doi.org/10.3390/pathogens5010015 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zec, Kristina
Volke, Julia
Vijitha, Nirojah
Thiebes, Stephanie
Gunzer, Matthias
Kurts, Christian
Engel, Daniel Robert
Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
title Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
title_full Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
title_fullStr Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
title_full_unstemmed Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
title_short Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages
title_sort neutrophil migration into the infected uroepithelium is regulated by the crosstalk between resident and helper macrophages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810136/
https://www.ncbi.nlm.nih.gov/pubmed/26861402
http://dx.doi.org/10.3390/pathogens5010015
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