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The T Cell Response to Staphylococcus aureus
Staphylococcus aureus (S. aureus) is a dangerous pathogen and a leading cause of both nosocomial and community acquired bacterial infection worldwide. However, on the other hand, we are all exposed to this bacterium, often within the first hours of life, and usually manage to establish equilibrium a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810152/ https://www.ncbi.nlm.nih.gov/pubmed/26999219 http://dx.doi.org/10.3390/pathogens5010031 |
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author | Bröker, Barbara M. Mrochen, Daniel Péton, Vincent |
author_facet | Bröker, Barbara M. Mrochen, Daniel Péton, Vincent |
author_sort | Bröker, Barbara M. |
collection | PubMed |
description | Staphylococcus aureus (S. aureus) is a dangerous pathogen and a leading cause of both nosocomial and community acquired bacterial infection worldwide. However, on the other hand, we are all exposed to this bacterium, often within the first hours of life, and usually manage to establish equilibrium and coexist with it. What does the adaptive immune system contribute toward lifelong control of S. aureus? Will it become possible to raise or enhance protective immune memory by vaccination? While in the past the S. aureus-specific antibody response has dominated this discussion, the research community is now coming to appreciate the role that the cellular arm of adaptive immunity, the T cells, plays. There are numerous T cell subsets, each with differing functions, which together have the ability to orchestrate the immune response to S. aureus and hence to tip the balance between protection and pathology. This review summarizes the state of the art in this dynamic field of research. |
format | Online Article Text |
id | pubmed-4810152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48101522016-04-04 The T Cell Response to Staphylococcus aureus Bröker, Barbara M. Mrochen, Daniel Péton, Vincent Pathogens Article Staphylococcus aureus (S. aureus) is a dangerous pathogen and a leading cause of both nosocomial and community acquired bacterial infection worldwide. However, on the other hand, we are all exposed to this bacterium, often within the first hours of life, and usually manage to establish equilibrium and coexist with it. What does the adaptive immune system contribute toward lifelong control of S. aureus? Will it become possible to raise or enhance protective immune memory by vaccination? While in the past the S. aureus-specific antibody response has dominated this discussion, the research community is now coming to appreciate the role that the cellular arm of adaptive immunity, the T cells, plays. There are numerous T cell subsets, each with differing functions, which together have the ability to orchestrate the immune response to S. aureus and hence to tip the balance between protection and pathology. This review summarizes the state of the art in this dynamic field of research. MDPI 2016-03-17 /pmc/articles/PMC4810152/ /pubmed/26999219 http://dx.doi.org/10.3390/pathogens5010031 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bröker, Barbara M. Mrochen, Daniel Péton, Vincent The T Cell Response to Staphylococcus aureus |
title | The T Cell Response to Staphylococcus aureus |
title_full | The T Cell Response to Staphylococcus aureus |
title_fullStr | The T Cell Response to Staphylococcus aureus |
title_full_unstemmed | The T Cell Response to Staphylococcus aureus |
title_short | The T Cell Response to Staphylococcus aureus |
title_sort | t cell response to staphylococcus aureus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810152/ https://www.ncbi.nlm.nih.gov/pubmed/26999219 http://dx.doi.org/10.3390/pathogens5010031 |
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