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Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior

Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral...

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Autores principales: Gotardo, André T., Pfister, James A., Raspantini, Paulo C. F., Górniak, Silvana L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810219/
https://www.ncbi.nlm.nih.gov/pubmed/26999204
http://dx.doi.org/10.3390/toxins8030074
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author Gotardo, André T.
Pfister, James A.
Raspantini, Paulo C. F.
Górniak, Silvana L.
author_facet Gotardo, André T.
Pfister, James A.
Raspantini, Paulo C. F.
Górniak, Silvana L.
author_sort Gotardo, André T.
collection PubMed
description Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral effects of prenatal ingestion of this plant on dams and their kids. Twenty-four pregnant goats were randomly allocated into four treatment groups and received the following doses (g/kg BW) of fresh I. carnea: 0 (control group), 1.0 (IC1), 3.0 (IC3), and 5.0 (IC5) from day 27 of gestation until parturition. Dam and kid bonding and behavior were evaluated by several tests, immediately after birth until six weeks of age. Dams from IC3 and IC5 groups spent less time paying attention to the newborn. There was a lack of maternal-infant bonding due to I. carnea intoxication. Kids from treated dams had difficulty in standing, suckling, and in recognizing their mother hours after birth. I. carnea can also compromise the kids’ ability to learn and to retain spatial memory. We suggest that kids from pregnant goats given I. carnea during gestation have significant behavioral alterations and developmental delays that may compromise their survival.
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spelling pubmed-48102192016-04-04 Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior Gotardo, André T. Pfister, James A. Raspantini, Paulo C. F. Górniak, Silvana L. Toxins (Basel) Article Ipomoea carnea is a toxic plant found in Brazil and other tropical and subtropical countries and often causes poisoning of livestock. The plant contains the alkaloids swainsonine and calystegines, which inhibit key cellular enzymes and cause systematic cell death. This study evaluated the behavioral effects of prenatal ingestion of this plant on dams and their kids. Twenty-four pregnant goats were randomly allocated into four treatment groups and received the following doses (g/kg BW) of fresh I. carnea: 0 (control group), 1.0 (IC1), 3.0 (IC3), and 5.0 (IC5) from day 27 of gestation until parturition. Dam and kid bonding and behavior were evaluated by several tests, immediately after birth until six weeks of age. Dams from IC3 and IC5 groups spent less time paying attention to the newborn. There was a lack of maternal-infant bonding due to I. carnea intoxication. Kids from treated dams had difficulty in standing, suckling, and in recognizing their mother hours after birth. I. carnea can also compromise the kids’ ability to learn and to retain spatial memory. We suggest that kids from pregnant goats given I. carnea during gestation have significant behavioral alterations and developmental delays that may compromise their survival. MDPI 2016-03-16 /pmc/articles/PMC4810219/ /pubmed/26999204 http://dx.doi.org/10.3390/toxins8030074 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gotardo, André T.
Pfister, James A.
Raspantini, Paulo C. F.
Górniak, Silvana L.
Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior
title Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior
title_full Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior
title_fullStr Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior
title_full_unstemmed Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior
title_short Maternal Ingestion of Ipomoea carnea: Effects on Goat-Kid Bonding and Behavior
title_sort maternal ingestion of ipomoea carnea: effects on goat-kid bonding and behavior
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810219/
https://www.ncbi.nlm.nih.gov/pubmed/26999204
http://dx.doi.org/10.3390/toxins8030074
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