Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature

Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated...

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Autores principales: Mosimann, Vincent, Blazek, Claudia, Grob, Heini, Chaney, Matthew, Neumayr, Andreas, Blum, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810230/
https://www.ncbi.nlm.nih.gov/pubmed/27042675
http://dx.doi.org/10.1093/ofid/ofw008
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author Mosimann, Vincent
Blazek, Claudia
Grob, Heini
Chaney, Matthew
Neumayr, Andreas
Blum, Johannes
author_facet Mosimann, Vincent
Blazek, Claudia
Grob, Heini
Chaney, Matthew
Neumayr, Andreas
Blum, Johannes
author_sort Mosimann, Vincent
collection PubMed
description Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML.
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spelling pubmed-48102302016-04-01 Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature Mosimann, Vincent Blazek, Claudia Grob, Heini Chaney, Matthew Neumayr, Andreas Blum, Johannes Open Forum Infect Dis Brief Reports Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that compare treatment options for these diseases. We compiled a case series of 24 cases successfully treated with miltefosine. We conclude that oral miltefosine is an effective treatment option for both OWCL and OWML. Oxford University Press 2016-02-01 /pmc/articles/PMC4810230/ /pubmed/27042675 http://dx.doi.org/10.1093/ofid/ofw008 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Mosimann, Vincent
Blazek, Claudia
Grob, Heini
Chaney, Matthew
Neumayr, Andreas
Blum, Johannes
Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature
title Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature
title_full Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature
title_fullStr Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature
title_full_unstemmed Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature
title_short Miltefosine for Mucosal and Complicated Cutaneous Old World Leishmaniasis: A Case Series and Review of the Literature
title_sort miltefosine for mucosal and complicated cutaneous old world leishmaniasis: a case series and review of the literature
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810230/
https://www.ncbi.nlm.nih.gov/pubmed/27042675
http://dx.doi.org/10.1093/ofid/ofw008
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