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The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice
Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810261/ https://www.ncbi.nlm.nih.gov/pubmed/27072420 http://dx.doi.org/10.3390/v8030071 |
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author | Warfield, Kelly L. Barnard, Dale L. Enterlein, Sven G. Smee, Donald F. Khaliq, Mansoora Sampath, Aruna Callahan, Michael V. Ramstedt, Urban Day, Craig W. |
author_facet | Warfield, Kelly L. Barnard, Dale L. Enterlein, Sven G. Smee, Donald F. Khaliq, Mansoora Sampath, Aruna Callahan, Michael V. Ramstedt, Urban Day, Craig W. |
author_sort | Warfield, Kelly L. |
collection | PubMed |
description | Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in mice. In the current study, the breadth of activity of UV-4B against influenza was examined ex vivo and in vivo. Efficacy of UV-4B against influenza A and B viruses was shown in primary human bronchial epithelial cells, a principal target tissue for influenza. Efficacy of UV-4B against influenza A (H1N1 and H3N2 subtypes) and influenza B was demonstrated using multiple lethal mouse models with readouts including mortality and weight loss. Clinical trials are ongoing to demonstrate safety of UV-4B and future studies to evaluate antiviral activity against influenza in humans are planned. |
format | Online Article Text |
id | pubmed-4810261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48102612016-04-04 The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice Warfield, Kelly L. Barnard, Dale L. Enterlein, Sven G. Smee, Donald F. Khaliq, Mansoora Sampath, Aruna Callahan, Michael V. Ramstedt, Urban Day, Craig W. Viruses Communication Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in mice. In the current study, the breadth of activity of UV-4B against influenza was examined ex vivo and in vivo. Efficacy of UV-4B against influenza A and B viruses was shown in primary human bronchial epithelial cells, a principal target tissue for influenza. Efficacy of UV-4B against influenza A (H1N1 and H3N2 subtypes) and influenza B was demonstrated using multiple lethal mouse models with readouts including mortality and weight loss. Clinical trials are ongoing to demonstrate safety of UV-4B and future studies to evaluate antiviral activity against influenza in humans are planned. MDPI 2016-03-07 /pmc/articles/PMC4810261/ /pubmed/27072420 http://dx.doi.org/10.3390/v8030071 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Warfield, Kelly L. Barnard, Dale L. Enterlein, Sven G. Smee, Donald F. Khaliq, Mansoora Sampath, Aruna Callahan, Michael V. Ramstedt, Urban Day, Craig W. The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice |
title | The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice |
title_full | The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice |
title_fullStr | The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice |
title_full_unstemmed | The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice |
title_short | The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice |
title_sort | iminosugar uv-4 is a broad inhibitor of influenza a and b viruses ex vivo and in mice |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810261/ https://www.ncbi.nlm.nih.gov/pubmed/27072420 http://dx.doi.org/10.3390/v8030071 |
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