Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis

Presynaptic differentiation is a critical and poorly understood step in synapse formation. Using compartmentalized culture systems that isolate axons and nascent synapses, Pinto et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509039) show that the axonal ubiquitin–proteasome system loca...

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Detalles Bibliográficos
Autores principales: Kim, Ju Youn, Jaffrey, Samie R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810311/
https://www.ncbi.nlm.nih.gov/pubmed/27022088
http://dx.doi.org/10.1083/jcb.201603028
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author Kim, Ju Youn
Jaffrey, Samie R.
author_facet Kim, Ju Youn
Jaffrey, Samie R.
author_sort Kim, Ju Youn
collection PubMed
description Presynaptic differentiation is a critical and poorly understood step in synapse formation. Using compartmentalized culture systems that isolate axons and nascent synapses, Pinto et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509039) show that the axonal ubiquitin–proteasome system locally regulates the accumulation of ubiquitinated substrates, triggering presynaptic differentiation.
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spelling pubmed-48103112016-09-28 Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis Kim, Ju Youn Jaffrey, Samie R. J Cell Biol Reviews Presynaptic differentiation is a critical and poorly understood step in synapse formation. Using compartmentalized culture systems that isolate axons and nascent synapses, Pinto et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509039) show that the axonal ubiquitin–proteasome system locally regulates the accumulation of ubiquitinated substrates, triggering presynaptic differentiation. The Rockefeller University Press 2016-03-28 /pmc/articles/PMC4810311/ /pubmed/27022088 http://dx.doi.org/10.1083/jcb.201603028 Text en © 2016 Kim and Jaffrey This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Kim, Ju Youn
Jaffrey, Samie R.
Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis
title Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis
title_full Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis
title_fullStr Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis
title_full_unstemmed Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis
title_short Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis
title_sort separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810311/
https://www.ncbi.nlm.nih.gov/pubmed/27022088
http://dx.doi.org/10.1083/jcb.201603028
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