Cargando…

Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex machineries. Both activities are essential for the s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sauvage, Eric, Terrak, Mohammed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810414/ https://www.ncbi.nlm.nih.gov/pubmed/27025527 http://dx.doi.org/10.3390/antibiotics5010012

Ejemplares similares

Peptidoglycan Glycosyltransferase Substrate Mimics as Templates for the Design of New Antibacterial Drugs
por: Derouaux, Adeline, et al.
Publicado: (2013)

Development of New Drugs for an Old Target — The Penicillin Binding Proteins
por: Zervosen, Astrid, et al.
Publicado: (2012)

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae
por: Li, Yuan, et al.
Publicado: (2016)

Both the transglycosylase and transpeptidase functions in plastid penicillin-binding protein are essential for plastid division in Physcomitrella patens
por: TAKAHASHI, Yoshiko, et al.
Publicado: (2016)

Non-classical transpeptidases yield insight into new antibacterials
por: Kumar, Pankaj, et al.
Publicado: (2016)

Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis
por: Leclercq, Sophie, et al.
Publicado: (2017)

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin‐binding protein PonA1 reveal potential mechanisms of antibiotic resistance
por: Filippova, Ekaterina V., et al.
Publicado: (2016)

SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli
por: Pazos, Manuel, et al.
Publicado: (2020)

Septal Class A Penicillin-Binding Protein Activity and ld-Transpeptidases Mediate Selection of Colistin-Resistant Lipooligosaccharide-Deficient Acinetobacter baumannii
por: Kang, Katie N., et al.
Publicado: (2021)

New Noncovalent Inhibitors of Penicillin-Binding Proteins from Penicillin-Resistant Bacteria
por: Turk, Samo, et al.
Publicado: (2011)

2806. The Mechanism of β-Lactam Antibiotic Action: Structural Analysis of Mycobacterium abscessus l,d-Transpeptidases, d,d-Carboxypeptidase and penicillin-binding-proteins binding by imipenem, ceftaroline, and amoxicillin
por: Shin, Eunjeong, et al.
Publicado: (2023)

Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b
por: Boes, Adrien, et al.
Publicado: (2020)

Evaluation of the Antibacterial Activities of Mangrove Honeybee Propolis Extract and the Identification of Transpeptidase and Transglycosylase as Targets for New Antibiotics Using Molecular Docking
por: Alshiekheid, Maha A.
Publicado: (2023)

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity
por: O’Daniel, Peter I., et al.
Publicado: (2014)

Crystal Structure of Penicillin-Binding Protein 3 (PBP3) from Escherichia coli
por: Sauvage, Eric, et al.
Publicado: (2014)

Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity
por: Triboulet, Sébastien, et al.
Publicado: (2013)

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity
por: Zuegg, Johannes, et al.
Publicado: (2015)

Proteomics and Docking Study Targeting Penicillin-Binding Protein and Penicillin-Binding Protein2a of Methicillin-Resistant Staphylococcus aureus Strain SO-1977 Isolated from Sudan
por: Mohamed, Sofia B, et al.
Publicado: (2019)

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase
por: Ahmad, Nazia, et al.
Publicado: (2022)

New Helical Binding Domain Mediates a Glycosyltransferase Activity of a Bifunctional Protein
por: Zhang, Hua, et al.
Publicado: (2016)

Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model
por: Temime, L., et al.
Publicado: (2003)

Protein Engineering of Penicillin Acylase
por: Tishkov, V.I., et al.
Publicado: (2010)

Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria
por: Asli, Abdelhamid, et al.
Publicado: (2016)

Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to lymphocyte ratio in a sample of Chinese Han population
por: Chen, Weijie, et al.
Publicado: (2022)

Penicillin Binding Proteins as Danger Signals: Meningococcal Penicillin Binding Protein 2 Activates Dendritic Cells through Toll-Like Receptor 4
por: Hill, Marcelo, et al.
Publicado: (2011)

Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins
por: Zapun, André, et al.
Publicado: (2016)

The Role of Glycosyltransferases in Colorectal Cancer
por: Fernández-Ponce, Cecilia, et al.
Publicado: (2021)

Higher plant glycosyltransferases
por: Ross, Joe, et al.
Publicado: (2001)

An Electrochemical Method to Detect Gamma Glutamyl Transpeptidase
por: Chen, Guifang, et al.
Publicado: (2012)

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins
por: Hayes, Andrew, et al.
Publicado: (2020)

β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview
por: Sethuvel, Dhiviya Prabaa Muthuirulandi, et al.
Publicado: (2023)

Biotin Protein Ligase Is a Target for New Antibacterials
por: Feng, Jiage, et al.
Publicado: (2016)

A Plasmodesmal Glycosyltransferase-Like Protein
por: Zalepa-King, Lisa, et al.
Publicado: (2013)

Promiscuity and specificity of eukaryotic glycosyltransferases
por: Biswas, Ansuman, et al.
Publicado: (2020)

Penicillin Therapy
Publicado: (1946)

Penicillin Therapy
Publicado: (1947)

A New Penicillin?
por: Wainwright, Mark
Publicado: (2020)

Structural Insights into Substrate Binding and Antibiotic Inhibition of Enterobacterial Penicillin-Binding Protein 6
por: Salleh, Mohd Zulkifli, et al.
Publicado: (2022)

301. Penicillin Versus Cefazolin or Anti-staphylococcal Penicillins for Penicillin-Susceptible Staphylococcus aureus Bacteremia
por: Aldhaeefi, Mohammed, et al.
Publicado: (2020)

Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity
por: Ren, Zhi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ja5pk4kiu6q18rilne5s39gbtc