An Essential Role for the Transcription Factor Runx1 in T Cell Maturation

The transcription factor Runx1 has essential roles throughout hematopoiesis. Here, we demonstrate that Runx1 is critical for T cell maturation. Peripheral naïve CD4(+) T cells from CD4-cre Runx1 cKO mice are phenotypically and functionally immature as shown by decreased production of TNF-α upon TCR...

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Detalles Bibliográficos
Autores principales: Hsu, Fan-Chi, Shapiro, Michael J., Dash, Barsha, Chen, Chien-Chang, Constans, Megan M., Chung, Ji Young, Romero Arocha, Sinibaldo R., Belmonte, Paul J., Chen, Meibo W., McWilliams, Douglas C., Shapiro, Virginia Smith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810436/
https://www.ncbi.nlm.nih.gov/pubmed/27020276
http://dx.doi.org/10.1038/srep23533

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