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Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture In Vitro

Clinical human cytomegalovirus (HCMV) strains invariably mutate when propagated in vitro. Mutations in gene RL13 are selected in all cell types, whereas in fibroblasts mutants in the UL128 locus (UL128L; genes UL128, UL130, and UL131A) are also selected. In addition, sporadic mutations are selected...

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Detalles Bibliográficos
Autores principales:	Murrell, Isa, Wilkie, Gavin S., Davison, Andrew J., Statkute, Evelina, Fielding, Ceri A., Tomasec, Peter, Wilkinson, Gavin W. G., Stanton, Richard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Genetic Diversity and Evolution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810542/ https://www.ncbi.nlm.nih.gov/pubmed/26842472 http://dx.doi.org/10.1128/JVI.02858-15

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