SPOC: A widely distributed domain associated with cancer, apoptosis and transcription

BACKGROUND: The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. RESULTS: We describe undetected members...

Descripción completa

Detalles Bibliográficos
Autores principales: Sánchez-Pulido, Luis, Rojas, Ana M, van Wely, Karel H, Martinez-A, Carlos, Valencia, Alfonso
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC481055/
https://www.ncbi.nlm.nih.gov/pubmed/15239844
http://dx.doi.org/10.1186/1471-2105-5-91
_version_ 1782121643044241408
author Sánchez-Pulido, Luis
Rojas, Ana M
van Wely, Karel H
Martinez-A, Carlos
Valencia, Alfonso
author_facet Sánchez-Pulido, Luis
Rojas, Ana M
van Wely, Karel H
Martinez-A, Carlos
Valencia, Alfonso
author_sort Sánchez-Pulido, Luis
collection PubMed
description BACKGROUND: The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. RESULTS: We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods. CONCLUSIONS: The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.
format Text
id pubmed-481055
institution National Center for Biotechnology Information
language English
publishDate 2004
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-4810552004-07-23 SPOC: A widely distributed domain associated with cancer, apoptosis and transcription Sánchez-Pulido, Luis Rojas, Ana M van Wely, Karel H Martinez-A, Carlos Valencia, Alfonso BMC Bioinformatics Research Article BACKGROUND: The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. RESULTS: We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods. CONCLUSIONS: The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality. BioMed Central 2004-07-07 /pmc/articles/PMC481055/ /pubmed/15239844 http://dx.doi.org/10.1186/1471-2105-5-91 Text en Copyright © 2004 Sánchez-Pulido et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Sánchez-Pulido, Luis
Rojas, Ana M
van Wely, Karel H
Martinez-A, Carlos
Valencia, Alfonso
SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
title SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
title_full SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
title_fullStr SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
title_full_unstemmed SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
title_short SPOC: A widely distributed domain associated with cancer, apoptosis and transcription
title_sort spoc: a widely distributed domain associated with cancer, apoptosis and transcription
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC481055/
https://www.ncbi.nlm.nih.gov/pubmed/15239844
http://dx.doi.org/10.1186/1471-2105-5-91
work_keys_str_mv AT sanchezpulidoluis spocawidelydistributeddomainassociatedwithcancerapoptosisandtranscription
AT rojasanam spocawidelydistributeddomainassociatedwithcancerapoptosisandtranscription
AT vanwelykarelh spocawidelydistributeddomainassociatedwithcancerapoptosisandtranscription
AT martinezacarlos spocawidelydistributeddomainassociatedwithcancerapoptosisandtranscription
AT valenciaalfonso spocawidelydistributeddomainassociatedwithcancerapoptosisandtranscription

Ejemplares similares