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MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy

Mengovirus, a member of the Picornaviridae family, has a broad cell tropism and can cause encephalitis and myocarditis in multiple mammalian species. Attenuation has been achieved by shortening the polycytidine tract in the 5′ noncoding region (NCR). A poly(C)-truncated strain of mengovirus, vMC(24)...

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Detalles Bibliográficos
Autores principales:	Ruiz, Autumn J., Hadac, Elizabeth M., Nace, Rebecca A., Russell, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810567/ https://www.ncbi.nlm.nih.gov/pubmed/26865716 http://dx.doi.org/10.1128/JVI.02810-15

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