Low-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering Particles

Low-fidelity RNA-dependent RNA polymerases for many RNA virus mutators have been shown to confer attenuated phenotypes, presumably due to increased mutation rates. Additionally, for many RNA viruses, replication to high titers results in the production of defective interfering particles (DIs) that a...

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Detalles Bibliográficos
Autores principales: Poirier, Enzo Z., Mounce, Bryan C., Rozen-Gagnon, Kathryn, Hooikaas, Peter Jan, Stapleford, Kenneth A., Moratorio, Gonzalo, Vignuzzi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810721/
https://www.ncbi.nlm.nih.gov/pubmed/26676773
http://dx.doi.org/10.1128/JVI.02921-15

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