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Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux
Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases(1). To date, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-1...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810788/ https://www.ncbi.nlm.nih.gov/pubmed/26814970 http://dx.doi.org/10.1038/nature16959 |