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Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma

BACKGROUND: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more common lesions such as dentigerous and radicular...

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Autores principales: Hormozi, Elham, Fard, Vahid Nourollahi, Naseri, Mohammad Ali, Jahromi, Nima Haghighat, Keshani, Forooz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810907/
https://www.ncbi.nlm.nih.gov/pubmed/27076824
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author Hormozi, Elham
Fard, Vahid Nourollahi
Naseri, Mohammad Ali
Jahromi, Nima Haghighat
Keshani, Forooz
author_facet Hormozi, Elham
Fard, Vahid Nourollahi
Naseri, Mohammad Ali
Jahromi, Nima Haghighat
Keshani, Forooz
author_sort Hormozi, Elham
collection PubMed
description BACKGROUND: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more common lesions such as dentigerous and radicular cysts. CD10 antigen is a cell surface metalloendopeptidase, which inactivates various peptides that are physiologically active. Studies have shown that increase in the expression of CD10 in the stromal cells helps the progression of the tumor. Ameloblastoma (AB) is a local invasive tumor and given the role of supporting connective tissue stroma in the aggression and progression. The aim of the present study was to comparatively evaluate the expression of CD10 in the connective tissue stroma of AB and OKC as a KCOT. MATERIALS AND METHODS: In this retrospective, cross-sectional study, 14 paraffin blocks of KCOT and 9 of AB (7 multicystic and 2 unicystic) were evaluated with CD10 immunohistochemical expression in the connective tissue stroma of AB and the connective tissue wall of KCOT. The data were analyzed with Fisher's exact test (P < 0.05). RESULTS: In 8 samples of 9 AB and in 13 samples of 14 KOT lesions, expression of CD10 was shown. Fisher's exact test did not reveal any significant differences between these two lesions in the expression of CD10 (P = 0.64). CONCLUSION: The results of this study propose that high expression rate of CD10 might be one of the reasons for the aggressive behavior of AB and high recurrence rate of OKC and reinforce the classification of OKC as an odontogenic tumor.
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spelling pubmed-48109072016-04-13 Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma Hormozi, Elham Fard, Vahid Nourollahi Naseri, Mohammad Ali Jahromi, Nima Haghighat Keshani, Forooz Dent Res J (Isfahan) Original Article BACKGROUND: Odontogenic keratocyst (OKC), also called keratocystic odontogenic tumor (KCOT), is a developmental lesion which should be carefully monitored and it exhibits development mechanisms and biologic behaviors different from those of other more common lesions such as dentigerous and radicular cysts. CD10 antigen is a cell surface metalloendopeptidase, which inactivates various peptides that are physiologically active. Studies have shown that increase in the expression of CD10 in the stromal cells helps the progression of the tumor. Ameloblastoma (AB) is a local invasive tumor and given the role of supporting connective tissue stroma in the aggression and progression. The aim of the present study was to comparatively evaluate the expression of CD10 in the connective tissue stroma of AB and OKC as a KCOT. MATERIALS AND METHODS: In this retrospective, cross-sectional study, 14 paraffin blocks of KCOT and 9 of AB (7 multicystic and 2 unicystic) were evaluated with CD10 immunohistochemical expression in the connective tissue stroma of AB and the connective tissue wall of KCOT. The data were analyzed with Fisher's exact test (P < 0.05). RESULTS: In 8 samples of 9 AB and in 13 samples of 14 KOT lesions, expression of CD10 was shown. Fisher's exact test did not reveal any significant differences between these two lesions in the expression of CD10 (P = 0.64). CONCLUSION: The results of this study propose that high expression rate of CD10 might be one of the reasons for the aggressive behavior of AB and high recurrence rate of OKC and reinforce the classification of OKC as an odontogenic tumor. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4810907/ /pubmed/27076824 Text en Copyright: © Dental Research Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Hormozi, Elham
Fard, Vahid Nourollahi
Naseri, Mohammad Ali
Jahromi, Nima Haghighat
Keshani, Forooz
Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma
title Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma
title_full Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma
title_fullStr Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma
title_full_unstemmed Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma
title_short Comparison of immunohistochemical expression of CD10 in keratocystic odontogenic tumor and ameloblastoma
title_sort comparison of immunohistochemical expression of cd10 in keratocystic odontogenic tumor and ameloblastoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810907/
https://www.ncbi.nlm.nih.gov/pubmed/27076824
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